×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
CLINVAR
Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.
12865922
2003
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
CausalMutation
group
CLINVAR
Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.
12865922
2003
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
BEFREE
LKB1 is a serine-threonine protein kinase mutated in patients with an autosomal dominantly inherited cancer syndrome predisposing to multiple benign and malignant tumours, termed Peutz-Jeghers syndrome.
12829253
2003
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
CausalMutation
group
CLINVAR
High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome.
16287113
2005
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
CLINVAR
An unusual case of sex cord tumor with annular tubules with malignant transformation in a patient with Peutz-Jeghers syndrome.
19952941
2010
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
CausalMutation
group
CLINVAR
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.
9887330
1999
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
CausalMutation
group
CLINVAR
Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome.
17404884
2007
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
CLINVAR
High prevalence of germline STK11 mutations in Hungarian Peutz-Jeghers Syndrome patients.
21118512
2010
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
BEFREE
Peutz-Jeghers Syndrome (PJS) is a hereditary cancer predisposing syndrome caused by autosomal dominant mutations in the serine/threonine kinase 11 (STK11 ) gene and is associated with decreased life expectancy.
29720104
2018
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
CLINVAR
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.
19892943
2009
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
CLINVAR
Cancer risks in LKB1 germline mutation carriers.
16407375
2006
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
CLINVAR
STK11 genotyping and cancer risk in Peutz-Jeghers syndrome.
15863673
2005
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
CausalMutation
group
CLINVAR
Two novel mutations and a new STK11/LKB1 gene isoform in Peutz-Jeghers patients.
12112668
2002
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
CausalMutation
group
CLINVAR
Mutations in the human LKB1/STK11 gene.
16110486
2005
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
CLINVAR
Frequency and spectrum of cancers in the Peutz-Jeghers syndrome.
16707622
2006
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
CausalMutation
group
CLINVAR
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.
19892943
2009
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
CausalMutation
group
CLINVAR
An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites.
15608654
2005
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
CLINVAR
Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma.
11389158
2001
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
CausalMutation
group
CLINVAR
STK11 genotyping and cancer risk in Peutz-Jeghers syndrome.
15863673
2005
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
CausalMutation
group
CLINVAR
Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome.
9760200
1998
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
CLINVAR
Relative frequency and morphology of cancers in STK11 mutation carriers.
15188174
2004
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
CausalMutation
group
CLINVAR
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.
9428765
1998
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
CausalMutation
group
CLINVAR
Genetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates.
17924967
2007
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
CLINVAR
Predicting the functional effect of amino acid substitutions and indels.
23056405
2012
×
Entrez Id:
6794
Gene Symbol:
STK11
STK11
0.120
GeneticVariation
group
CLINVAR
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.
9887330
1999