Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.080 | Biomarker | phenotype | BEFREE | However, CCR2 is also implicated in other inflammatory diseases such as rheumatoid arthritis, multiple sclerosis, asthma, and neuropathic pain. | 29251559 | 2019 | ||||
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0.080 | Biomarker | phenotype | BEFREE | It was previously shown that administration of CCR2 antagonists induces analgesic effects; however, the role of CCR2 ligands in neuropathic pain still needs to be explained. | 31003094 | 2019 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | In conclusion, our study supports that CCR2 inhibition could be explored as an interventional approach to reduce microglia activation and consequently neuropathic pain development after peripheral nerve injury. | 31150565 | 2019 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | Because the TRPV1 and MCP-1/CCR2 pathways are implicated in chronic neuropathic pain, we explored their role in post-UTI chronic pain. | 29739958 | 2018 | ||||
|
0.080 | AlteredExpression | phenotype | BEFREE | Chemokine signaling is important in neuropathic pain, with microglial cells expressing chemokine (C-C motif) receptor CCR2, CCR5 and CCR8, all playing key roles. | 29248693 | 2018 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell. | 29993042 | 2018 | ||||
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0.080 | Biomarker | phenotype | BEFREE | Our data provide new evidence that CCR2 is a promising target for diminishing neuropathic pain and enhancing the opioid analgesic effects. | 28337574 | 2017 | ||||
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0.080 | AlteredExpression | phenotype | BEFREE | We found that in a focal demyelination model of neuropathic pain both MCP-1 and CCR2 were up-regulated by the same neurons including transient receptor potential vanilloid receptor subtype 1 (TRPV1) expressing nociceptors. | 17944871 | 2008 |