Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.400 AlteredExpression phenotype BEFREE Furthermore, we found that miR-129-5p alleviated neuropathic pain through downregulating high mobility group protein B1 (HMGB1) expression in CCI rats as overexpression of miR-129-5p suppressed expression of both HMGB1 and proinflammatory cytokine and alleviated pain sensation in CCI rats. 31489582 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Our research findings confirm that cannabinoid treatment produces significant improvements in neurological disability scoring and behavioral assessments of NPP that directly result from their ability to reduce tumor necrosis factor alpha (TNF-α) production and enhance brain derived neurotrophic factor (BDNF) production. 31213295 2019
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.400 Biomarker phenotype BEFREE The current study aimed to characterize neuropathic pain-induced changes in affect over time and to determine whether HMGB1 has a role in neuropathic pain-induced changes in affect. 30763674 2019
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
0.400 Biomarker phenotype BEFREE PERSPECTIVE: This study demonstrates that a MOR-DOR dual agonist given chronically in chronic neuropathic pain models has enhanced efficacy with strongly reduced tolerance and dependence, with a further anti-inflammatory effect in the spinal cord. 31201990 2019
Entrez Id: 2915
Gene Symbol: GRM5
GRM5
0.400 Biomarker phenotype BEFREE We successfully elucidated the degree of pain-sensing behavior using the neuropathic pain-specific pattern of the mGluR5 availability. 29990583 2019
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
0.400 Biomarker phenotype BEFREE We further show that the inhibitory function of MOR is impaired during neuropathic pain. 31316354 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression phenotype BEFREE TNF-α/STAT3 pathway epigenetically upregulates Nav1.6 expression in DRG and contributes to neuropathic pain induced by L5-VRT. 30736806 2019
Entrez Id: 2915
Gene Symbol: GRM5
GRM5
0.400 Biomarker phenotype BEFREE Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain. 30970677 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Progressive Increase of Inflammatory CXCR4 and TNF-Alpha in the Dorsal Root Ganglia and Spinal Cord Maintains Peripheral and Central Sensitization to Diabetic Neuropathic Pain in Rats. 31001066 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE The positive interactions between TNF-α and ACC neurons might modulate the cytokine microenvironment thus contribute to the neuropathic pain. 31028871 2019
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.400 Biomarker phenotype BEFREE Since there is growing evidence that spinal MIF and HMGB1 mediate inflammatory and neuropathic pain we examined whether there were spinal changes occurring during persistent bladder pain that may be responsible for maintaining bladder pain. 30708129 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE PERSPECTIVE: This study presents a novel route of drug administration to target central TNF for treatment of neuropathic pain. 31376497 2019
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
0.400 PosttranslationalModification phenotype BEFREE These findings indicate that OCT1 may participate in neuropathic pain at least in part by transcriptionally activating Dnmt3a and subsequently epigenetic silencing of Oprm1 and Kcan2 in the DRG. 30247265 2019
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.400 Biomarker phenotype BEFREE We aim to explore whether 2Hz EA stimulation regulates the spinal HMGB1/NF-κB signaling in neuropathic pain induced by spared nerve injury (SNI). 31695479 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE Moreover, miR-144 negatively regulated neuroinflammation by decreasing the expression of proinflammatory mediators, including TNF-α (tumor necrosis factor-α), IL (interleukin)-1β, and IL-6, thus facilitating the inhibition of neuropathic pain development. 31737949 2019
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.400 AlteredExpression phenotype BEFREE This study aimed to explore the role of microRNA (miR)-193a in diabetic neuropathic pain through the regulation of HMGB1. 31665716 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE In addition, lipopolysaccharide-induced increase in tumor necrosis factor-α (TNF-α) in the hippocampus antagonized the beneficial effects of EE for these behavioral abnormalities in mice with neuropathic pain. 30798405 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression phenotype BEFREE Also, gene expression of tumor necrosis factor-α was higher in NL-1 patients compared with NL-0 (P < 0.05), and interleukin-1ß was higher, but IL-10 was lower in NL-1 patients compared with healthy controls (P < 0.05 each). 31145221 2019
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.400 Biomarker phenotype BEFREE By contrast, the cellular mechanism by which spinal HMGB1 induces neuropathic pain has yet to be fully elaborated. 31273787 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression phenotype BEFREE Knockdown of ANXA10 at the spinal cord level suppressed the SNL-induced hyperalgesia and blocked the activation of NF-κB, TNF-α and IL-1β both in the early and late phase of NP. 31208343 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker phenotype BEFREE The activation of NOD2 signaling in peripheral macrophage mediates the development of neuropathic pain through the production of pronociceptive cytokines (tumor necrosis factor and IL-1β). 30169421 2019
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
0.400 AlteredExpression phenotype BEFREE These findings suggest that DRG TET1 overexpression mitigated neuropathic pain likely through rescue of MOR and Kv1.2 expression in the ipsilateral DRG. 30515739 2019
Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
0.400 Biomarker phenotype BEFREE Moreover, evidences of neuroplastic changes that may underlie the low efficacy of MOR agonists under neuropathic pain conditions are reviewed and discussed. 30318675 2019
Entrez Id: 2915
Gene Symbol: GRM5
GRM5
0.400 AlteredExpression phenotype BEFREE Collectively, the results in this study indicated nerve injury diminishes spinal Hes1-dependent suppression of CDK9-dependent RNAPII phosphorylation on the mGluR5 promoter that possibly enhances mGluR5 transcription/expression for neuropathic pain development. 31454988 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression phenotype BEFREE Our results suggested that LG or LG-βCD produce anti-hyperalgesic effect in chronic pain models through reductions in TNF-α levels and PKA, and inhibited voltage-gated calcium channels and may be innovative therapeutic agents for the management of NP. 31654745 2019