Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 Biomarker disease BEFREE BRAF = v-raf murine sarcoma viral oncogene homolog B1 FLUS = follicular lesion of undetermined significance FNAB = fine-needle aspiration biopsy FTC = follicular thyroid carcinoma HRAS = homologous to the oncogene from the Harvey rat sarcoma virus KRAS = homologous to the oncogene from the Kirsten rat sarcoma virus NRAS = first isolated from a human neuroblastoma/neuroblastoma RAS = viral oncogene homolog PAX8 = paired box 8 PCR = polymerase chain reaction PPAR-gamma = peroxisome proliferator-activated receptor gamma PTC = papillary thyroid carcinoma RAS = rat sarcoma RET = rearranged during transfection tyrosine-kinase proto-oncogene SM = somatic mutation SNP = single-nucleotide polymorphism. 27214302 2016
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 Biomarker disease CTD_human Mutational dynamics between primary and relapse neuroblastomas. 26121086 2015
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 AlteredExpression disease BEFREE Here we describe a miRNA, miR-380-5p, that represses p53 expression via a conserved sequence in the p53 3' untranslated region (UTR). miR-380-5p is highly expressed in mouse embryonic stem cells and neuroblastomas, and high expression correlates with poor outcome in neuroblastomas with neuroblastoma derived v-myc myelocytomatosis viral-related oncogene (MYCN) amplification. miR-380 overexpression cooperates with activated HRAS oncoprotein to transform primary cells, block oncogene-induced senescence and form tumors in mice. 20871609 2010
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 Biomarker disease BEFREE Additionally, Ras family members (Hras1, Kras2 and Nras) and the downstream effectors Pik3ca and Braf, were sequenced from twenty-five neuroblastomas arising in neuroblastoma-prone transgenic mice. 16822308 2006
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 Biomarker disease CTD_human Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice. 15814359 2005
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 Biomarker disease BEFREE However, the amount of p21ras-GTP bound was higher in pPNET than in neuroblastoma cells. 9619634 1998
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 AlteredExpression disease BEFREE Favorable outcomes of patients with advanced NB were distinguished by high Ha-ras and high trk A expression, and unfavorable outcomes were distinguished by low Ha-ras and low trk A expression. 9781958 1998
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 AlteredExpression disease BEFREE To evaluate the correlation between telomerase activity and other biological characteristics reported as prognostic markers (MYCN gene amplification, loss of heterogeneity (LOH) in the short arm of chromosome 1, trk-A expression, Ha-ras p21 expression, and DNA ploidy), we investigated these biological features in 105 untreated neuroblastomas. 9516827 1997
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 AlteredExpression disease BEFREE These results suggest that, in neuroblastoma, activation of p21ras is not associated with RA-induced differentiation. 7576949 1995
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 AlteredExpression disease BEFREE N-myc amplification was found in neuroblastomas with low expression of trk A and of Ha-ras genes. 8625212 1995
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 Biomarker disease BEFREE Unfavorable DNA ploidy and Ha-ras p21 findings in neuroblastomas detected through mass screening. 8625168 1995
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 AlteredExpression disease BEFREE Prognostic prediction in neuroblastomas: clinical significance of combined analysis for Ha-ras p21 expression and N-myc gene amplification. 7982238 1994
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 Biomarker disease BEFREE These findings suggest that c-src and c-Ha-ras play important roles in the neural differentiation of infantile neuroblastomas. 2039993 1991
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 AlteredExpression disease BEFREE The expression of Ha-ras p21 was thought to be a clinically important marker for prognosis in children with neuroblastoma. 1873783 1991
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 Biomarker disease BEFREE These findings from unmanipulated human neuroblastomas indicate that the Ha-ras gene product (p21) might play a role in the mechanism(s) controlling aggressiveness in this type of tumor in vivo and that the Ha-ras p21 detected by a simple and reproducible immunohistochemical procedure may be of clinical importance in predicting prognosis in patients with this malignancy. 3276397 1988
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.600 CausalMutation disease CGI