Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 AlteredExpression disease BEFREE The results also establish that LIN28B overexpression supports neuroblastoma onset and the metastatic potential of malignant cells through let-7a-dependent and let-7a-independent mechanisms. 31601998 2020
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 AlteredExpression disease BEFREE By this study, a regulatory loop is proposed, wherein, ODC silencing in Y79 cells to result in decreased polyamine levels, thereby, leading to altered protein levels of Lin28b, MMP-2 and MMP-9, which falls in line with earlier studies in neuroblastoma. 29241071 2018
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 GeneticVariation disease BEFREE We also found that the combination of polymorphisms in CASC15, LIN28B, and LMO1 may be used to predict neuroblastoma risk (AUC=0.63, 95% CI=0.59-0.67). 29024823 2017
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 GeneticVariation disease GWASCAT Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma. 28545128 2017
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 GeneticVariation disease BEFREE With the purpose to evaluate the association between LIN28B gene polymorphisms and neuroblastoma susceptibility in Southern Chinese population, we conducted this study with 256 neuroblastoma cases and 531 cancer-free controls. 27021521 2016
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 Biomarker disease BEFREE Here we show, however, that LIN28B is dispensable in MYCN-amplified neuroblastoma cell lines, despite de-repression of let-7. 27383785 2016
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 AlteredExpression disease BEFREE We show that MYCN regulates LIN28B expression in neuroblastoma tumors via two distinct parallel mechanisms. 26123663 2015
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 AlteredExpression disease BEFREE In vitro experiments using NB cell lines, BE(2)-C, SMS-KCNR, and CHLA90 show that DFMO treatment reduced LIN28B and MYCN protein levels and increased Let-7 miRNA and decreased neurosphere formation. 25415050 2015
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 GeneticVariation disease BEFREE In a genome-wide association study, we identified single-nucleotide polymorphisms (SNP) associated with neuroblastoma at the CASC15, BARD1, LMO1, DUSP12, HSD17B12, HACE1, and LIN28B gene loci, but these explain only a small fraction of neuroblastoma heritability. 25312269 2014
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 GeneticVariation disease BEFREE Several neuroblastoma (NB) susceptibility loci have been identified within LINC00340, BARD1, LMO1, DUSP12, HSD17B12, DDX4, IL31RA, HACE1 and LIN28B by genome-wide association (GWA) studies including European American individuals. 23222812 2013
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 Biomarker disease CTD_human Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression. 22941191 2012
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 SusceptibilityMutation disease ORPHANET The relationship between hygiene and microbial burden in atopic dermatitis risk based on a systematic review. 22911191 2012
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 GeneticVariation disease BEFREE Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression. 22941191 2012
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 GeneticVariation disease GWASCAT Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression. 22941191 2012
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 AlteredExpression disease BEFREE These findings were fully recapitulated in a mouse model in which LIN28B expression in the sympathetic adrenergic lineage induced development of neuroblastomas marked by low let-7 miRNA levels and high MYCN protein expression. 23042116 2012
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 Biomarker disease CTD_human These findings were fully recapitulated in a mouse model in which LIN28B expression in the sympathetic adrenergic lineage induced development of neuroblastomas marked by low let-7 miRNA levels and high MYCN protein expression. 23042116 2012
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 GeneticVariation disease GWASDB Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression. 22941191 2012
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
0.900 Biomarker disease MGD
Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
0.800 Biomarker disease BEFREE The only common CNV across all tumors was 17q gain, with differing chromosomal coordinates across samples but a common region of overlap distal to 17q21.31, suggesting this adverse prognostic biomarker may offer insight about additional drivers for multifocal neuroblastoma in patients with germline PHOX2B or NF1 aberrations. 31515834 2020
Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
0.800 AlteredExpression disease BEFREE The role of β-catenin and paired-like homeobox 2B (PHOX2B) expression in neuroblastoma patients; predictive and prognostic value. 31220430 2019
Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
0.800 Biomarker disease BEFREE Interestingly, the forced expression of NR4A3 induced only the GAP43 but not the other molecules involved in NB cell differentiation, such as MYCN, TRKA, and PHOX2B. 31183633 2019
Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
0.800 Biomarker disease BEFREE High levels of bone marrow TH and PHOX2B and of peripheral blood PHOX2B at diagnosis allow early identification of a group of high-risk infant and toddlers with neuroblastoma who may be candidates for alternative treatments. 29603574 2018
Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
0.800 GeneticVariation disease BEFREE Approximately 1-2% of neuroblastomas are inherited in an autosomal dominant fashion and a combination of co-morbidity and linkage studies has led to the identification of germline mutations in PHOX2B and ALK as the major genetic contributors to this familial neuroblastoma subset. 29589100 2018
Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
0.800 Biomarker disease BEFREE Given the central role of PHOX2B in the pathogenesis of CCHS, and the progesterone-mediated effects observed in the disease, we generated progesterone-responsive neuroblastoma cells, and evaluated the effects of 3-Ketodesogestrel (3-KDG), the biologically active metabolite of desogestrel, on the expression of PHOX2B and its target genes. 30036539 2018
Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
0.800 Biomarker disease BEFREE Phox2b immunohistochemistry (IHC) was performed on 159 paediatric tumours, including (group 1) 65 neural crest tumours with neuronal differentiation [peripheral neuroblastic tumours (pNT)]: 15 neuroblastoma undifferentiated (NB-UD), 10 NB poorly differentiated (NB-PD), 10 NB differentiating (NB-D), 10 ganglioneuroblastoma intermixed (GNBi), 10 GNB nodular (GNBn) and 10 ganglioneuroma (GN); (group 2) 23 neural crest tumours with neuroendocrine differentiation [pheochromocytoma/paraganglioma (PCC/PG)]; (group 3) 27 other neural crest tumours including one composite rhabdomyosarcoma/neuroblastoma; and (group 4) 44 non-neural crest tumours. 28986989 2018