Nine patients experienced neutropenia (Absolute neutrophil count [ANC] ≤ 1200mm3) and the estimated cumulative incidence at 3 months is 0.29% (95% confidence interval, 0.13%- 0.54%).
Duration of neutropenia (ANC < 500/mm³) ≥7 days represents an independent risk factor for CMV complications, where neutropenia most likely represents a crude surrogate biomarker indicating a deeper and longer state of overall immunosuppression.
In sub-lethally-irradiated mice, ANC nadir remained >200/mm<sup>3</sup> and neutropenia recovered in 6days with ST7 treatment and 18days in controls (p<0.05).
Seventy-two had severe neutropenia at the time of port insertion (absolute neutrophil count [ANC] range, 0-500/mm<sup>3</sup>; mean, 185/mm<sup>3</sup>).