×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
Biomarker
disease
GENOMICS_ENGLAND
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
Biomarker
disease
HPO
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
GeneticVariation
disease
BEFREE
Our results suggest that mutations in the BRAF gene and to some extent in the N-ras gene represent early somatic events that occur in melanocytic nevi .
15009715
2004
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
GeneticVariation
disease
BEFREE
In addition, NRAS mutations were found in 2/11 (18.2%) CAN s and 3/12 (25%) CMs.
15252839
2004
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
GeneticVariation
disease
BEFREE
BRAF and NRAS mutations in melanoma and melanocytic nevi .
16845322
2006
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
GeneticVariation
disease
LHGDN
BRAF and NRAS mutations in melanoma and melanocytic nevi .
16845322
2006
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
Biomarker
disease
BEFREE
Our results suggest that although nevus propensity is important for the occurrence of both BRAF and NRAS -mutant melanomas, ambient UV irradiance influences risk differently based on the age of exposure.
17507627
2007
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
GeneticVariation
disease
BEFREE
Both Spitz naevi and spitzoid melanoma had a lower combined BRAF and NRAS mutation frequency compared with common acquired naevi (P = 0.0001) and common forms of melanoma (P = 0.0072), respectively.
19438459
2009
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
Biomarker
disease
GENOMICS_ENGLAND
A restricted spectrum of NRAS mutations causes Noonan syndrome.
19966803
2010
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
GeneticVariation
disease
BEFREE
In this series the presence of a BRAF- or NRAS mutation in a nevus was not associated with the risk of malignant transformation.
23861977
2013
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
Biomarker
disease
GENOMICS_ENGLAND
Multilineage somatic activating mutations in HRAS and NRAS cause mosaic cutaneous and skeletal lesions, elevated FGF23 and hypophosphatemia.
24006476
2014
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
GeneticVariation
disease
BEFREE
In vitro, 1 in 250 cells from fresh lCMN formed colonies that could be passaged and harbored the same NRAS mutation as the original nevus .
25310409
2015
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
GeneticVariation
disease
BEFREE
Focused amplicon deep sequencing on DNA extracted from the brain tumor and a cutaneous nevus revealed a heterozygous (c.37G>C; p.G13R ) substitution in the NRAS gene.
25330907
2014
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
GeneticVariation
disease
BEFREE
All BRAF wild-type naevi (15%; n = 6/40) harboured an NRAS codon 12/13 or 61 mutation.
28714107
2018
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
0.500
GeneticVariation
disease
BEFREE
These findings document that common conjunctival melanocytic nevi have mutually exclusive mutations in BRAF and NRAS .
29332123
2018