Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 Biomarker disease BEFREE Given that a slower CYP2A6 metabolism has been associated with less vulnerability to develop nicotine dependence, the current studies sought to validate a novel CYP2A6 inhibitor, (5-(4-ethylpyridin-3-yl)thiophen-2-yl)methanamine (DLCI-1), for its effects on intravenous nicotine self-administration. 31628204 2020
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 Biomarker disease CTD_human The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings. 28472521 2018
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 Biomarker disease BEFREE Therefore, we evaluated the possible association between SNPs in CYP2A6 with cigarette smoking and nicotine addiction-related variables in Mexican mestizo smokers. 28734893 2017
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 Biomarker disease BEFREE Because the CYP2A6 effect was seen only in smokers, these data suggest that the rate of nicotine metabolism-and thus the concentration of nicotine presented to the brain over the course of nicotine addiction-shapes brain circuits that, among other functions, compute reward and impulsivity processes. 27865452 2017
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 GeneticVariation disease BEFREE Distribution of polymorphic variants of CYP2A6 and their involvement in nicotine addiction. 28507465 2017
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 GeneticVariation disease BEFREE The present study sought to identify time-dependent within-participant effects of CYP2A6 genotypes on smoking frequency and nicotine dependence in young smokers. 25744963 2016
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 Biomarker disease CTD_human Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers. 26644138 2016
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 GeneticVariation disease BEFREE For nicotine and metabolite levels, function of the cytochrome P450 2A6 liver enzyme, which can be assessed with the nicotine metabolite ratio or via genotype, has been found to predict response, with slow nicotine metabolizers having less severe nicotine dependence and a greater likelihood of quitting with NRT than normal metabolizers. 25895022 2015
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 Biomarker disease BEFREE This study investigated whether polymorphisms of the ankyrin repeat and kinase domain containing 1 gene (ANKK1), which is adjacent to the dopamine D2 receptor gene (DRD2), and the dopamine transporter (SLC6A3) and cytochrome P450 2A6 (CYP2A6) genes influence smoking cessation and nicotine dependence in a Japanese population. 25526961 2014
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 GeneticVariation disease BEFREE CYP2A6 genotype is not associated with nicotine dependence, as defined by the Fagerström Test of Nicotine Dependence, demonstrating that cigarettes smoked per day (CPD) and nicotine dependence have distinct genetic correlates. 22451501 2012
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 Biomarker disease CTD_human CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people. 22569203 2012
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 GeneticVariation disease BEFREE We found a significant genotype effect (all P≤0.017) for the following smoking-related phenotypes: (i) cigarettes smoked per day and CYP2A13*3; (ii) pack years smoked and CYP2A6*2, CYP2A6*1×2, CYP2A13*7, CYP2B6*4 and DRD2-ANKK1 2137G>A (Taq1A); (iii) nicotine dependence (assessed with the Fagestrom test) and CYP2A6*9. 22046326 2011
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 GeneticVariation disease BEFREE Cigarette consumption (P < .001) and nicotine dependence (P = .036) were the highest in the combined CYP2A6 normal metabolizers and CHRNA5-A3-B4 AA (tag single-nucleotide polymorphism rs1051730 G>A) risk group. 21747048 2011
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 Biomarker disease BEFREE Among the genes at the two newly associated loci are genes encoding nicotine-metabolizing enzymes (CYP2A6 and CYP2B6) and nicotinic acetylcholine receptor subunits (CHRNB3 and CHRNA6), all of which have been highlighted in previous studies of smoking and nicotine dependence. 20418888 2010
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 Biomarker disease BEFREE The psychoactive compound responsible for tobacco addiction, nicotine and the potent carcinogens present at high concentrations either in cigarette mainstream smoke or in smokeless tobacco products, 4-(methylnitrosamino)-1-(3-pyridyl)-butanone (NNK) and N-nitrosonornicotine (NNN) can be metabolized by CYP2A6. 19018727 2008
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 GeneticVariation disease BEFREE Initial smoking experiences did not account for how CYP2A6 genetic variation impacts nicotine dependence. 17130279 2007
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 GeneticVariation disease BEFREE We performed a survey on the relationship between nicotine dependence and psychological (the personality traits using neuroticism extroversion openess-five factor inventory (NEO-FFI)/nicotine metabolism (the CYP2A6 gene polymorphism) factors among Japanese young students to elucidate the mechanism of the development of nicotine dependence. 17934923 2007
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 Biomarker disease CTD_human Smoking cessation program and CYP2A6 polymorphism. 16720336 2006
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 GeneticVariation disease BEFREE Collectively, CYP2A6 genotypes are related with nicotine dependence, influencing smoking habits and withdrawal symptoms in quitting smoking. 16402086 2006
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 GeneticVariation disease BEFREE Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence. 15735609 2005
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 Biomarker disease CTD_human Case control studies in adults suggest that defective alleles in the gene that codes for the hepatic cytochrome P450 2A6 (CYP2A6) protect against nicotine dependence (ND) and higher levels of cigarette consumption. 15564629 2004
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 Biomarker disease BEFREE Case control studies in adults suggest that defective alleles in the gene that codes for the hepatic cytochrome P450 2A6 (CYP2A6) protect against nicotine dependence (ND) and higher levels of cigarette consumption. 15564629 2004
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 GeneticVariation disease BEFREE Further research is needed in order to improve our understanding of how genetic variation in CYP2A6 alters the risk for nicotine dependence and lowers nicotine consumption. 11768189 1999
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.400 GeneticVariation disease BEFREE Among Caucasians, an additional defective and frequently distributed allele (CYP2A6*3) has been suggested to play a protective role against nicotine addiction and cigarette consumption. 10544257 1999