×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Diagnosis of Noonan syndrome and related disorders using target next generation sequencing.
24451042
2014
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.
24803665
2014
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma.
23026937
2013
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.
22892241
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins.
23093928
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Prevalence and clinical features of Costello syndrome and cardio-facio-cutaneous syndrome in Japan: findings from a nationwide epidemiological survey.
22495831
2012
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Non-hodgkin lymphoma in a patient with cardiofaciocutaneous syndrome.
20523244
2011
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors.
19376813
2009
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.
19206169
2009
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
GeneticVariation
disease
CLINVAR
Biochemical characterization of novel germline BRAF and MEK mutations in cardio-facio-cutaneous syndrome.
18413255
2008
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
In one patient with NS , we also identified a mutation, BRAF K499E, that has previously been reported in patients with CFC.
18456719
2008
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Biochemical characterization of novel germline BRAF and MEK mutations in cardio-facio-cutaneous syndrome.
18413255
2008
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors.
18953432
2008
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome.
18042262
2008
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome.
17704260
2007
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
GeneticVariation
disease
CLINVAR
Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome.
17704260
2007
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Germline gain-of-function mutations in RAF1 cause Noonan syndrome.
17603482
2007
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
GeneticVariation
disease
CLINVAR
Molecular and clinical characterization of cardio-facio-cutaneous (CFC) syndrome: overlapping clinical manifestations with Costello syndrome.
17366577
2007
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression.
16953233
2007
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
GeneticVariation
disease
CLINVAR
Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy.
18060073
2007
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Neurological complications of cardio-facio-cutaneous syndrome.
18039235
2007
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome.
16439621
2006
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.
16474404
2006
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.770
CausalMutation
disease
CLINVAR
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.
15035987
2004