Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1088
Gene Symbol: CEACAM8
CEACAM8
0.010 Biomarker disease BEFREE Of the 86 studied proteins, 4 were found to be independently associated with hypertension: GDF-15, LEP, SORT-1 and FABP-2; 3 with obesity: CEACAM-8, LEP and PRELP; and 4 with diabetes: GDF-15, REN, CXCL-1 and SCF. 31062082 2020
Entrez Id: 56920
Gene Symbol: SEMA3G
SEMA3G
0.010 Biomarker disease BEFREE SEMA3G inhibition may, therefore, be useful for treating diet-induced obesity and its complications. 31648186 2020
Entrez Id: 104355217
Gene Symbol: ERICD
ERICD
0.010 Biomarker disease BEFREE We systematically searched MEDLINE, EMBASE, PsycINFO, and ERIC databases for studies which included the search terms "obesity education" AND either "medical students", "residency", or "fellowship" that met PICOS (Population, Interventions, Comparators, Outcomes, Study Design) criteria for articles published in English for obesity education and evaluation of outcomes. 31551484 2020
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.010 Biomarker disease BEFREE Further, the number of fragmented mitochondria and Drp1(Ser<sup>616</sup>) phosphorylation were trended to reduce/reduced (0.0104, 95% CI [0.0085, 0.0126], P = 0.091 and 0.0085, 95% CI [0.0068, 0.0102], P = 0.05) in myotubes derived from severely obese humans at 7 months after RYGB surgery in comparison with the presurgery state. 31624314 2020
Entrez Id: 100616317
Gene Symbol: MIR4777
MIR4777
0.010 AlteredExpression disease BEFREE In a sample of 135 unrelated subjects, 35 children with obesity (between ages 3 and 13) and 100 healthy controls (between ages 4 and 16), we examined the expression levels of four candidate miRNAs (<i>hsa-miR-4777-3p, hsa-miR-642b-3p, hsa-miR-3671-1, and hsa-miR-551b-</i>2) targeting the <i>PLIN1</i> as measured by real-time polymerase chain reaction in whole blood samples. 31851864 2020
Entrez Id: 608
Gene Symbol: TNFRSF17
TNFRSF17
0.010 Biomarker disease BEFREE Further, it is hypothesised that BCM-7 may influence fractures and obesity via μ-opioid receptor pathways. 31154909 2020
Entrez Id: 8562
Gene Symbol: DENR
DENR
0.010 Biomarker disease BEFREE Further, the number of fragmented mitochondria and Drp1(Ser<sup>616</sup>) phosphorylation were trended to reduce/reduced (0.0104, 95% CI [0.0085, 0.0126], P = 0.091 and 0.0085, 95% CI [0.0068, 0.0102], P = 0.05) in myotubes derived from severely obese humans at 7 months after RYGB surgery in comparison with the presurgery state. 31624314 2020
Entrez Id: 693136
Gene Symbol: MIR551B
MIR551B
0.010 AlteredExpression disease BEFREE In a sample of 135 unrelated subjects, 35 children with obesity (between ages 3 and 13) and 100 healthy controls (between ages 4 and 16), we examined the expression levels of four candidate miRNAs (<i>hsa-miR-4777-3p, hsa-miR-642b-3p, hsa-miR-3671-1, and hsa-miR-551b-</i>2) targeting the <i>PLIN1</i> as measured by real-time polymerase chain reaction in whole blood samples. 31851864 2020
Entrez Id: 27035
Gene Symbol: NOX1
NOX1
0.010 Biomarker disease BEFREE In summary, the current data support a main role for Nox1-derived O<sub>2</sub><sup>.-</sup> in kidney vascular oxidative stress and renal endothelial dysfunction in obesity, while reduced endothelial Nox4 expression associated to decreased H<sub>2</sub>O<sub>2</sub> generation and H<sub>2</sub>O<sub>2</sub>-mediated vasodilatation might hinder Nox4 protective renal effects thus contributing to kidney injury. 31563085 2020
Entrez Id: 1080
Gene Symbol: CFTR
CFTR
0.010 GeneticVariation disease BEFREE In the entire cohort, overweight/obese were likely to be older (OR = 1.04, p < 0.0001) and to have a mild CFTR genotype (OR = 3.33, p = 0.0003) and modestly elevated triglyceride levels (OR = 1.008, p < 0.0001). 31727452 2020
Entrez Id: 1400
Gene Symbol: CRMP1
CRMP1
0.010 Biomarker disease BEFREE Further, the number of fragmented mitochondria and Drp1(Ser<sup>616</sup>) phosphorylation were trended to reduce/reduced (0.0104, 95% CI [0.0085, 0.0126], P = 0.091 and 0.0085, 95% CI [0.0068, 0.0102], P = 0.05) in myotubes derived from severely obese humans at 7 months after RYGB surgery in comparison with the presurgery state. 31624314 2020
Entrez Id: 50943
Gene Symbol: FOXP3
FOXP3
0.010 AlteredExpression disease BEFREE In contrast, lower levels of mRNA FOXP3 expression was detected in ATMC from individuals with obesity that correlated with methylation percentage of FOXP3 gene but no association with miR-155 was detected. 31136754 2019
Entrez Id: 23066
Gene Symbol: CAND2
CAND2
0.010 Biomarker disease BEFREE Detecting epistasis within chromatin regulatory circuitry identified CAND2 as a novel obesity susceptibility gene. 29717274 2019
Entrez Id: 406980
Gene Symbol: MIR19B1
MIR19B1
0.010 GeneticVariation disease BEFREE In addition, these genes are targeted by miRNAs related to schizophrenia (mir-34a) and obesity (mir-19b). 31447353 2019
Entrez Id: 135
Gene Symbol: ADORA2A
ADORA2A
0.010 Biomarker disease BEFREE These findings indicate that Adora2a-mediated signaling in vascular endothelial cells disrupts the BBB in dietary obesity, and implicate cerebrovascular dysfunction as the underlying mechanism for deficits in synaptic plasticity and cognition with obesity and insulin resistance.<b>SIGNIFICANCE STATEMENT</b> The blood-brain barrier (BBB) restricts the entry of circulating factors into the brain, but obesity promotes BBB breakdown in humans and animal models. 30886019 2019
Entrez Id: 3320
Gene Symbol: HSP90AA1
HSP90AA1
0.010 Biomarker disease BEFREE This study aimed to determine the anti-obesity effect of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein 90 (Hsp90) inhibitor, and its underlying mechanism in rats with ovariectomy-induced obesity. 31336120 2019
Entrez Id: 100532731
Gene Symbol: COMMD3-BMI1
COMMD3-BMI1
0.010 GeneticVariation disease BEFREE Inclusion criteria were: BMI ≥ 1 SD; term birth; no genetic or endocrine causes of obesity; no associated chronic diseases neither chronic therapies. 31316471 2019
Entrez Id: 6348
Gene Symbol: CCL3
CCL3
0.010 Biomarker disease BEFREE Both MIP-1α and free fatty acids are elevated in obesity/T2D. 30816669 2019
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.010 Biomarker disease BEFREE Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons. 31230943 2019
Entrez Id: 57787
Gene Symbol: MARK4
MARK4
0.010 Biomarker disease BEFREE These results suggest that MARK4 promotes lipid accumulation in porcine placental trophoblasts and can be considered as a potential regulator of lipotoxicity associated with maternal obesity in the pig placenta. 30857324 2019
Entrez Id: 100129193
Gene Symbol: MUPP
MUPP
0.010 Biomarker disease BEFREE The genetic background is an important factor explaining MHP and MUP related to obesity, in addition to lifestyle variables. 31555433 2019
Entrez Id: 10869
Gene Symbol: USP19
USP19
0.010 Biomarker disease BEFREE Thus, this study aimed to provide further understanding of the role of ubiquitin-specific peptidase 19 (USP19) in fat development, obesity and diabetes. 30386869 2019
Entrez Id: 154091
Gene Symbol: SLC2A12
SLC2A12
0.010 Biomarker disease BEFREE We hypothesize that GLUT12 would contribute to modulate sugar absorption in physiological and pathophysiological situations such as obesity. 31002200 2019
Entrez Id: 118490
Gene Symbol: MSS51
MSS51
0.010 Biomarker disease BEFREE These findings demonstrate that MSS51 modulates skeletal muscle mitochondrial respiration and regulates whole-body glucose and fatty acid metabolism, making it a potential target for obesity and diabetes. 31527314 2019
Entrez Id: 253935
Gene Symbol: ANGPTL5
ANGPTL5
0.010 AlteredExpression disease BEFREE This study was designed to investigate the expression levels of ANGPTL5 protein in the circulation of subjects with obesity and T2D. 31396158 2019