Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE These findings indicate that HSPA12A is a novel regulator of adipocyte differentiation and diet-induced obesity through a positive feedback regulation with PPARγ. 30742088 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE These results suggest that the combined regulation of PPARγ, SMAD and the adrenergic receptor signalling pathway synergistically induces brown adipogenesis and may serve as an effective strategy to treat obesity and related diseases, including type 2 diabetes. 31317231 2019
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 Biomarker disease BEFREE Single SNP analysis showed that genetic variants in SLC30A10, TMEM18, GNPDA2, PRL, TFAP2B, BDNF, MTCH2, FTO, and MC4R were nominally associated with waist circumference (WC), BMI, and risk for abdominal or general obesity in the untreated patients with type 2 diabetes, as well as in the total group of patients with type 2 diabetes (untreated and treated) (p < 0.05). 31167208 2019
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 Biomarker disease BEFREE MC4R-KO mice fed an HFD developed obesity and NASH. 30465867 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Loss of μ-crystallin causes PPARγ activation and obesity in high-fat diet-fed mice. 30545633 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Obesity rats induced by 8-week high fat diet (HFD) were randomly divided into obesity group (OB) and exercised obesity group (EOB) with 8 rats each group, and 40 diabetes rats established by 8-week HFD plus low dose of streptozotocin were randomly divided into 4 groups: diabetes group (DM), exercised diabetes group (EDM), exercised diabetes plus PPARγ agonist pioglitazone group (EDP), and exercised diabetes plus PPARγ antagonist GW9662 group (EDG). 30873215 2019
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Our results suggested that FTO rs9939609, MC4R rs12970134, and MC4R rs17782313 are strongly associated with obesity. 30896429 2019
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 Biomarker disease BEFREE Immunoglobulin G modulation of the melanocortin 4 receptor signaling in obesity and eating disorders. 30755592 2019
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 Biomarker disease BEFREE When the melanocortin 4 receptor (MC4R) is knocked out globally, male mice display obesity, low sexual desire, and copulatory difficulties; however, it is unclear whether these phenotypes are interdependent. 30756300 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Thus, PPARγ agonists are of -interest in the therapeutic approach to treat CKD in the context of obesity. 30625473 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Here we dissected the specific role of high-fat-diet (HFD)-induced obesity and vascular smooth muscle cell (VSMC)-PPARγ for remodelling of small pulmonary arteries. 30813929 2019
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Gain-of-function variants in the melanocortin 4 receptor gene confer susceptibility to binge eating disorder in subjects with obesity: a systematic review and meta-analysis. 30306707 2019
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Our study pointed out the role of MC4R rs17782313 and ENPP1 rs1044498 genotypes in obesity determinisms in mothers and their newborns in correlation with BMI, MUAC, TST and bioimpedance parameters. 31350533 2019
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Association study between LEPR, MC4R polymorphisms and overweight/obesity in Chinese Han adolescents. 30641221 2019
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE In addition, BDNF rs6265 and MC4R rs17782313 showed gender-dependent associations with decreased risk of having low HDL-C in males and increased risk of having abdominal obesity in females, respectively. 31502573 2019
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 Biomarker disease BEFREE Melanocortin-4 receptor (<i>MC4R</i>) has been reported to be associated with the risk of obesity, and metabolically unhealthy obese (MUHO) patients tend to have a greater risk of cardiovascular complications than metabolically healthy obese (MHO) patients. 31781208 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE It was found that resistin expression is significantly correlated with lipid profile and inflammatory status in obesity and atherosclerotic groups, and PPARγ agonist administration significantly improves inflammatory status and dyslipidemic profile across studied groups (p < .05). 30612469 2019
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 Biomarker disease BEFREE However, when MC4R-deficient rats were food restricted to prevent obesity, CIH-induced hypertension was attenuated by 32%. 30466186 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE We further show that in the context of diet-induced obesity PPARγ-K107R-mutant mice have enhanced insulin sensitivity without the corresponding increase in adiposity that typically accompanies PPARγ activation by TZDs. 30420515 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE MiR-27a derived from these adipocytes induced insulin resistance in C2C12 skeletal muscle cells through miR-27a-mediated repression of PPARγ and its downstream genes involved in the development of obesity. 29721071 2018
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Women with extreme obesity carrying rs17782313 MC4R polymorphism present a higher pre-surgical BMI, are more unlikely to reach non-obesity BMI (<30 kg/m<sup>2</sup>) and tend to maintain a BMI > 35 kg/m<sup>2</sup> that characterize treatment failure. 28579220 2018
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE Heterozygous loss-of-function MC4R mutations are the most common known genetic cause of monogenic human obesity, with more than 200 mutations described to date, affecting 2-3% of the population in various cohorts tested. 30068297 2018
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 GeneticVariation disease BEFREE The artificial distinction between rare monogenic obesity and common polygenic obesity is now obsolete with the identification of MC4R variants of strong effect in the general population. 30121879 2018
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
1.000 Biomarker disease BEFREE Thus, liraglutide induced an equal, clinically significant weight loss of 6% in both groups, indicating that the appetite-reducing effect of liraglutide is preserved in MC4R causal obesity and that liraglutide acts independently of the MC4R pathway. 29861388 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE These results suggest that CD38 deficiency impairs adipogenesis and lipogenesis through activating Sirt1/PPARγ-FASN signalling pathway during the development of obesity. 28816006 2018