Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.370 Biomarker disease BEFREE The Dualistic Effect of COX-2-Mediated Signaling in Obesity and Insulin Resistance. 31247902 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.370 Biomarker disease BEFREE The relative abundance of FGFR2 and DNMT1 was influenced by maternal obesity status and conceptus sex, and the abundance of PPARG and PTGS2 transcripts was greater in male conceptuses regardless of the obesity status of the ewe. 29764739 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.370 Biomarker disease BEFREE Targetted inhibition of CD74 attenuates adipose COX-2-MIF-mediated M1 macrophage polarization and retards obesity-related adipose tissue inflammation and insulin resistance. 29773671 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.370 Biomarker disease BEFREE Moreover, Raptor-deficient mice were resistant to diet-induced obesity and COX-2 downregulation. 30232001 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.370 GeneticVariation disease BEFREE Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038). 29321183 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.370 GeneticVariation disease BEFREE Also, the coexistence of COX-2 (rs2745557) and obesity, smoking, or diabetes may lead to the development of PCa or BPH. 26920155 2016
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.370 Biomarker disease CTD_human Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss. 21156398 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.370 Biomarker disease BEFREE These data indicate that heterozygous COX-2 mice develop obesity which is not secondary to a defect in leptin release by adipose tissue. 11444591 2001