Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.080 | Biomarker | disease | BEFREE | The Sapap3-KO model is thus a useful tool for future mechanistic studies to determine how mPFC hyperactivity contributes to OCD-relevant cognitive dysfunction. | 30587851 | 2019 | ||||
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0.080 | GeneticVariation | disease | BEFREE | Behavioral flexibility in a mouse model for obsessive-compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants. | 30688005 | 2019 | ||||
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0.080 | Biomarker | disease | BEFREE | In conclusion, only Sapap3-KO mice developed behavior that was fully insensitive to reward devaluation, suggesting that pathological habits in OCD patients are recapitulated in the present Sapap3-KO mouse model. | 31427755 | 2019 | ||||
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0.080 | GeneticVariation | disease | BEFREE | Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder | 30403026 | 2019 | ||||
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0.080 | Biomarker | disease | BEFREE | These data provide evidence of monoaminergic dysregulation in a translational model of OCD symptoms and are consistent with aberrant cortical and striatal serotonin and dopamine release/metabolism in SAPAP-3 KO mice. | 29352023 | 2018 | ||||
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0.080 | Biomarker | disease | BEFREE | Loss of SAPAP3 leads to obsessive-compulsive disorder (OCD)-like behaviors due to alterations in metabotropic glutamate receptor (mGluR) signaling. | 29908232 | 2018 | ||||
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0.080 | AlteredExpression | disease | BEFREE | SAP90/PSD95-associated protein 3 (SAPAP3/DLGAP3) is a post-synaptic scaffolding protein that is highly expressed in glutamatergic synapses in the striatum and has recently been investigated as a candidate gene in both OCD and GD studies. | 21184590 | 2011 | ||||
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0.080 | GeneticVariation | disease | BEFREE | In the current study, we sought to determine whether variation within the human Sapap3 gene was associated with grooming disorders (GDs: pathologic nail biting, pathologic skin picking, and/or trichotillomania) and/or obsessive-compulsive disorder (OCD) in 383 families thoroughly phenotyped for OCD genetic studies. | 19051237 | 2009 |