Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 58512
Gene Symbol: DLGAP3
DLGAP3
0.080 Biomarker disease BEFREE The Sapap3-KO model is thus a useful tool for future mechanistic studies to determine how mPFC hyperactivity contributes to OCD-relevant cognitive dysfunction. 30587851 2019
Entrez Id: 58512
Gene Symbol: DLGAP3
DLGAP3
0.080 GeneticVariation disease BEFREE Behavioral flexibility in a mouse model for obsessive-compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants. 30688005 2019
Entrez Id: 58512
Gene Symbol: DLGAP3
DLGAP3
0.080 Biomarker disease BEFREE In conclusion, only Sapap3-KO mice developed behavior that was fully insensitive to reward devaluation, suggesting that pathological habits in OCD patients are recapitulated in the present Sapap3-KO mouse model. 31427755 2019
Entrez Id: 58512
Gene Symbol: DLGAP3
DLGAP3
0.080 GeneticVariation disease BEFREE Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder 30403026 2019
Entrez Id: 58512
Gene Symbol: DLGAP3
DLGAP3
0.080 Biomarker disease BEFREE These data provide evidence of monoaminergic dysregulation in a translational model of OCD symptoms and are consistent with aberrant cortical and striatal serotonin and dopamine release/metabolism in SAPAP-3 KO mice. 29352023 2018
Entrez Id: 58512
Gene Symbol: DLGAP3
DLGAP3
0.080 Biomarker disease BEFREE Loss of SAPAP3 leads to obsessive-compulsive disorder (OCD)-like behaviors due to alterations in metabotropic glutamate receptor (mGluR) signaling. 29908232 2018
Entrez Id: 58512
Gene Symbol: DLGAP3
DLGAP3
0.080 AlteredExpression disease BEFREE SAP90/PSD95-associated protein 3 (SAPAP3/DLGAP3) is a post-synaptic scaffolding protein that is highly expressed in glutamatergic synapses in the striatum and has recently been investigated as a candidate gene in both OCD and GD studies. 21184590 2011
Entrez Id: 58512
Gene Symbol: DLGAP3
DLGAP3
0.080 GeneticVariation disease BEFREE In the current study, we sought to determine whether variation within the human Sapap3 gene was associated with grooming disorders (GDs: pathologic nail biting, pathologic skin picking, and/or trichotillomania) and/or obsessive-compulsive disorder (OCD) in 383 families thoroughly phenotyped for OCD genetic studies. 19051237 2009