Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE A significant association was detected between the BDNF polymorphism rs2883187 and OCD (p = .00). 31180700 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE But there was a marginally significant effect of the BDNF Val66Met variant on OCD in different ethnicity. 31291217 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE Regression analysis determined the extent to which psychiatric comorbidity, illness severity, OCD symptom dimensions, childhood trauma history, and the Val66Met (rs6265) polymorphism of the brainderived neurotrophic factor (BDNF) gene predict lifetime suicidal ideation and attempts in adults with OCD. 31046037 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression disease BEFREE We can conclude that transcriptional regulation of BDNF in OCD engages epigenetic mechanisms, and can suggest that this is likely evoked by the long-term pharmacotherapy. 31004918 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression disease BEFREE Cytokine, chemokine and BDNF levels in medication-free pediatric patients with obsessive-compulsive disorder. 29302747 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE In this study, we perform a case control analysis of association of a single nucleotide polymorphism rs6265(Val66Met) in Brain Derived Neurotrophic Factor gene, that has been previously implicated in a variety of psychiatric syndromes, and examine its association with symptom dimensions of OCD. 29079096 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker disease BEFREE Brain-derived neurotrophic factor (BDNF) is an interesting candidate for molecular analysis in OCD on the basis of potential functional relevance, positive association studies, and reported interaction between this gene and other neurotransmitters implicated in this disorder. 25710846 2015
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE Our study supports the involvement of the BDNF Val66Met polymorphism as a common genetic susceptibility for OCD and TS in the Chinese Han population, showing specific gender trends. 25771937 2015
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE The purpose of this study was to derive a more precise estimation of the association between BDNF Val66Met polymorphism and OCD susceptibility by a meta-analysis. 26503495 2015
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression disease BEFREE BDNF plasma/serum levels in OCD have been found lower than those in healthy controls. 26209750 2015
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE Further investigation based on larger populations is needed to reveal the full association of the BDNF polymorphism with OCD. 24291483 2014
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE Although no significant association was observed between BDNF Val66Met and the development of OCD, interaction analysis indicated that the BDNF Met-allele interacted with childhood emotional abuse to increase the risk of OCD significantly in a dose-dependent manner (p = 0.024). 24050777 2013
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE Our study replicated the association between BDNF Val66Met gene polymorphism and OCD. 23999029 2013
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker disease BEFREE BDNF promote the function and growth of 5-HT neurons in the brain and modulate the synaptic plasticity of DRD3-secreting neurons in the striatum, suggesting involvement of BDNF in the mediation of obsessive-compulsive disorder. 22521161 2012
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE These results demonstrate that the BDNF Val66Met polymorphism does not appear to be a risk factor for OCD. 22911909 2012
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker disease BEFREE In this article, we briefly review previous work regarding clinical and demographical factors associated with drug response in OCD, then focus on recent findings regarding candidate genes which may influence drug response, including those in the serotonin system, brain-derived neurotrophic factor and the glutamate transporter gene. 22176623 2012
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE Genetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms. 22153732 2012
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression disease BEFREE However BDNF plasma levels in those two OCD patients groups were not different from each other significantly (p=0.99). 21616543 2011
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE We examined the BDNF gene in a large (N=301) clinical sample of probands with OCD. 21668081 2011
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE A brain-derived neurotrophic factor haplotype is associated with therapeutic response in obsessive-compulsive disorder. 19589503 2009
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker disease BEFREE The results suggest that BDNF function may be implicated in the mediation of OCD. 19219856 2009
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE Haplotype analysis revealed a significant association between OCD and a five-marker protective haplotype located toward the 5' of the BDNF gene (odds ratio [OR] = .80; 95% confidence interval [CI] = .69-.92; permutation p value = .006) containing the functional valine (Val)66-to-methionine (Met) variant. 17884018 2008
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE As several other uncommon, less well quantitated genetic variations occur with an OCD phenotype, including chromosomal anomalies and some other rare gene variants (SGCE, GCH1 and SLITRK1), a tentative conclusion is that OCD resembles other complex disorders in being etiologically heterogeneous and in having both highly penetrant familial subtypes associated with rare alleles or chromosomal anomalies, as well as having a more common, polygenetic form that may involve polymorphisms in such genes as BDNF, COMT, GRIN2beta, TPH2, HTR2A and SLC1A1. 18197083 2008
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE The aim of the present study was to investigate the role that the val66met variant within the gene encoding brain-derived neurotrophic factor (BDNF) may play in mediating the development of selected OCD subtypes accounting for the aforementioned confounding factors. 17853300 2008
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder. 17375136 2007