Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.030 AlteredExpression disease BEFREE The immunoprofile of odontogenic keratocyst (keratocystic odontogenic tumor) that includes expression of PTCH, SMO, GLI-1 and bcl-2 is similar to ameloblastoma but different from odontogenic cysts. 19473442 2009
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.030 GeneticVariation disease LHGDN Germline mutations of the PTCH gene in families with odontogenic keratocysts and nevoid basal cell carcinoma syndrome. 16675912 2006
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
0.030 Biomarker disease BEFREE Immunolocalization of PTCH protein in odontogenic cysts and tumors. 12407090 2002
Entrez Id: 10630
Gene Symbol: PDPN
PDPN
0.020 AlteredExpression disease BEFREE Further, podoplanin expression was the highest in the suprabasal layer of NBCCS lesions, followed by the suprabasal layers of OK and OOC lesions. 31241560 2019
Entrez Id: 5111
Gene Symbol: PCNA
PCNA
0.020 GeneticVariation disease BEFREE Nerve sparing enucleation and curettage was employed for the established cases of Odontogenic Cysts; Enucleation and curettage, peripheral ostectomy, followed by chemical cauterization was employed for the Unicystic Ameloblastomas and other Odontogenic tumours with a low Ki-67 and PCNA Proliferation Index (PI)/Labelling index (LI ≤ 3); Marginal resection was carried out for the tumours with a higher Labelling Index (LI >3 ≤5), and Segmental resection (including partial/complete Maxillectomy, Hemimandibulectomy with/without disarticulation) for the aggressive pathologies with high Labelling Index (LI > 5). 31077874 2019
Entrez Id: 10630
Gene Symbol: PDPN
PDPN
0.020 Biomarker disease BEFREE Immunohistochemistry using monoclonal antibody against podoplanin and TGF-β was performed on 76 odontogenic cysts and tumors. 29577431 2018
Entrez Id: 84441
Gene Symbol: MAML2
MAML2
0.020 GeneticVariation disease BEFREE Assessment of biologically aggressive, recurrent glandular odontogenic cysts for mastermind-like 2 (MAML2) rearrangements: histopathologic and fluorescent in situ hybridization (FISH) findings in 11 cases. 29121421 2018
Entrez Id: 84441
Gene Symbol: MAML2
MAML2
0.020 Biomarker disease BEFREE The aim of this study was to investigate the presence of MAML2 rearrangement in ODCs featuring mucous prosoplasia. 25123064 2015
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.020 Biomarker disease BEFREE The immunoprofile of odontogenic keratocyst (keratocystic odontogenic tumor) that includes expression of PTCH, SMO, GLI-1 and bcl-2 is similar to ameloblastoma but different from odontogenic cysts. 19473442 2009
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.020 Biomarker disease BEFREE The glandular odontogenic cysts showed immunoreactivity for bcl-2 protein in the basal and suprabasal layers, while staining in dentigerous cysts was basal or focal. 10738941 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.020 Biomarker disease BEFREE Immunohistochemical study of bcl-2 protein, Ki-67 antigen and p53 protein in epithelium of glandular odontogenic cysts and dentigerous cysts. 10738941 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.020 AlteredExpression disease BEFREE The aim of this report was to assess p53 and MDM2 expression in odontogenic cysts and tumours, as they are known to play important roles in cell proliferation and tumorigenesis. 10483067 1999
Entrez Id: 5111
Gene Symbol: PCNA
PCNA
0.020 AlteredExpression disease BEFREE These results demonstrate differences in PCNA expression between the epithelial linings of the major odontogenic cyst types, indicating differences in proliferative and differentiation processes within these lesions. 7913971 1994
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.010 Biomarker disease BEFREE No significant difference in p16INK4a staining was noted between odontogenic cysts and the listed odontogenic tumors (chi-square, P = .540). 31680334 2020
Entrez Id: 2253
Gene Symbol: FGF8
FGF8
0.010 AlteredExpression disease BEFREE Dental organs of various odontogenic stages and 30 OTs including solid multicystic ameloblastomas (SMA, 10 cases), ameloblastic fibroma (AF, 10 cases), odontogenic myxoma (OM, 10 cases), and odontogenic cysts: odontogenic keratocyst (OKC, 10 cases) were evaluated in both epithelial and mesenchymal components for the expression of BMP4 and FGF8 using immunohistochemistry. 30079292 2018
Entrez Id: 7161
Gene Symbol: TP73
TP73
0.010 Biomarker disease BEFREE We carried out immunohistochemical analysis to evaluate the expression of p53, p63, and p73 in 60 samples of OC, including dentigerous cysts, radicular cysts, orthokeratinized OC, and odontogenic keratocysts (OKC). 30520832 2018
Entrez Id: 6657
Gene Symbol: SOX2
SOX2
0.010 AlteredExpression disease BEFREE With the accumulation of keratin in the stellate reticulum (SR) region and subsequent odontogenic cyst formation, SI cells gradually lost the ability to differentiate, and the expression of Sox2 and Notch1 was downregulated, leading to ameloblast depolarization. 29863959 2018
Entrez Id: 83478
Gene Symbol: ARHGAP24
ARHGAP24
0.010 Biomarker disease BEFREE We carried out immunohistochemical analysis to evaluate the expression of p53, p63, and p73 in 60 samples of OC, including dentigerous cysts, radicular cysts, orthokeratinized OC, and odontogenic keratocysts (OKC). 30520832 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.010 AlteredExpression disease BEFREE Caspase-3 was found to be overexpressed in all lesions, with the highest expression in odontogenic cysts compared to tumors. 28238093 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.010 Biomarker disease BEFREE Role of HIF-1α and CASPASE-3 in cystogenesis of odontogenic cysts and tumors. 28238093 2018
Entrez Id: 652
Gene Symbol: BMP4
BMP4
0.010 AlteredExpression disease BEFREE Dental organs of various odontogenic stages and 30 OTs including solid multicystic ameloblastomas (SMA, 10 cases), ameloblastic fibroma (AF, 10 cases), odontogenic myxoma (OM, 10 cases), and odontogenic cysts: odontogenic keratocyst (OKC, 10 cases) were evaluated in both epithelial and mesenchymal components for the expression of BMP4 and FGF8 using immunohistochemistry. 30079292 2018
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
0.010 AlteredExpression disease BEFREE With the accumulation of keratin in the stellate reticulum (SR) region and subsequent odontogenic cyst formation, SI cells gradually lost the ability to differentiate, and the expression of Sox2 and Notch1 was downregulated, leading to ameloblast depolarization. 29863959 2018
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.010 Biomarker disease BEFREE To analyse the immunoreactivity of IL-1α, TNF-α and IL-10 in odontogenic cysts and tumours and to investigate possible associations with established biological behaviours of these different lesions. 27009845 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.010 Biomarker disease BEFREE Immunoexpression of tumour necrosis factor-α, interleukin-1α and interleukin-10 on odontogenic cysts and tumours. 27009845 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.010 Biomarker disease BEFREE To analyse the immunoreactivity of IL-1α, TNF-α and IL-10 in odontogenic cysts and tumours and to investigate possible associations with established biological behaviours of these different lesions. 27009845 2017