Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 Biomarker disease BEFREE From these, sperm from 40 randomly selected men with no DAZ microdeletions in their leukocytes (n = 10 oligozoospermia; n = 10 asthenozoospermia; n = 10 oligoasthenozoospermia; and n = 10 near-azoospermia) were were compared to sperm from men of normal semen quality (n = 10) using combined primed in situ labelling and fluorescent in situ hybridization (PRINS-FISH) technique as well as screening for sex chromosome aneuploidy. 28521575 2018
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia. 27739146 2016
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE In men with AZFc subdeltions, loss of two DAZ and one CDY1 gene copy made them highly susceptible to azoospermia and severe oligozoospermia with OR of 29.7 and 26, respectively. 26149076 2015
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE More interestingly, partial DAZ1/2 deletion was associated with azoospermia (ORs=2.63, 95%CI: 1.19-5.81, I(2)=64.7%) and oligozoospermia (ORs=2.53, 95%CI: 1.40-4.57, I(2)=51.8%), but partial DAZ3/4 deletion was not associated with azoospermia (ORs=0.71, 95%CI: 0.23-2.22, I(2)=71.7%,) and oligozoospermia (ORs=1.21, 95%CI: 0.65-2.24, I(2)=55.5%). 26232607 2015
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE Analysis of DAZ gene copies in Tunisian population, suggested that the simultaneous deletion of DAZ2 and DAZ4 gene copies is associated with male infertility, and that oligospermia seems to be promoted by removing DAZ4 copy. 24878370 2014
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 Biomarker disease BEFREE Transmission of DAZ (Deleted in Azoospermia) microdeletion is one of the major concerns for oligo and severe oligozoospermia patients. 22648284 2012
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 Biomarker disease BEFREE Although AZFc is deleted in azoospermia or oligozoospermia, no definitive conclusion has been drawn for the role of partial AZFc deletions to spermatogenic failure. 20823911 2011
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE gr/gr deletions were analyzed by using markers sY1291, sY1191 and sY1197 and by investigating the presence of single nucleotide variants (SNV) in DAZ and CDY1 genes in patients with azoospermia (n = 44), cryptozoospermia (n = 51) or severe oligozoospermia (n = 92). 18326516 2008
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE Copy deletion screening of DAZ gene family on the Y chromosome in 485 patients with idiopathic azoospermia or oligozoospermia and 236 fertile men revealed that the prevalence of deletion patterns of the entire DAZ gene and DAZ1/DAZ2 gene were significantly higher in the patients than in fertile men. 16580401 2006
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE We conclude that partial deletions of the DAZ genes are associated with oligozoospermia but not with azoospermia; however, an increased number of DAZ genes does not seem to be a statistically significant risk factor for spermatogenic failure. 16275261 2005
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 AlteredExpression disease BEFREE The transcript ratios for BOULE, DAZL, and DAZ were significantly decreased in tissues with spermatogenic failure (hypospermatogenesis, maturation arrest, and Sertoli cell-only). 15066460 2004
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE To uncover the functional contribution of DAZ to human spermatogenesis, a DAZ gene copy-specific deletion analysis was previously established and showed that DAZ1/DAZ2 deletions associate with oligozoospermia. 15347736 2004
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE Twelve of 101 patients (12%) with the AZFc/DAZ microdeletion were found, including 8 with azoospermia (11%) and 4 with severe oligozoospermia (14.3%), and 1 patient had a AZFb and AZFc/DAZ double deletion. 11930664 2002
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE With these diagnostic tools, 63 DNA samples from men with idiopathic oligozoospermia and 107 DNA samples from men with proven fertility were analysed for the presence of the complete DAZ gene locus, encompassing the four DAZ gene copies. 11870237 2002
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE Such deletions determine azoospermia more frequently than severe oligozoospermia and involve especially the AZFc region including the DAZ gene family. 11294825 2001
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE This procedure could be particularly useful in screening for the DAZ locus in the diagnostic workup of nonobstructive azoospermia and severe oligoasthenoteratozoospermia. 10685522 2000
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE DNA screening tests for DAZ genes before ICSI may help in the genetic counseling of patients with idiopathic azoospermia or severe oligozoospermia. 10360905 1999
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE In a subset of infertile men, a spectrum of spermatogenic defects ranging from a complete absence of germ cells (sertoli cell only) to oligozoospermia is associated with microdeletions of the DAZ (deleted in azoospermia) gene cluster on human distal Yq. 10393944 1999
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 Biomarker disease BEFREE Deletions in the AZFc region involving the DAZ gene were the most frequent finding and they were more often observed in severe hypospermatogenesis than in Sertoli cell-only syndrome, suggesting that deletions of this region are not sufficient to cause complete loss of the spermatogenic line. 10402373 1999
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 GeneticVariation disease BEFREE The DAZLA (DAZ Like Autosomal) gene on human chromosome 3 shares a high degree of homology with the DAZ (Deleted in AZoospermia) gene family on the Y chromosome, a gene family frequently deleted in males with azoospermia or severe oligospermia. 9294855 1997
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 Biomarker disease BEFREE Clustering of Y chromosome deletions in subinterval E of interval 6 supports the existence of an oligozoospermia critical region outside the DAZ gene. 9391878 1997
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 Biomarker disease BEFREE Screening for deletions of the Y chromosome involving the DAZ (Deleted in AZoospermia) gene in azoospermia and severe oligozoospermia. 9091344 1997
Entrez Id: 1617
Gene Symbol: DAZ1
DAZ1
0.200 Biomarker disease HPO