Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 Biomarker disease BEFREE Taken together, these results revealed that miR-455-3p/COL2A1 axis might provide a novel molecular target for the treatment of OA. 31809639 2020
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 Biomarker disease BEFREE The aim of this study, was to describe the effect of a multistrain probiotic (PB) and chondroitin sulfate (CS), administered separately or in combination, on the expression of Ptgs2, Tgfb1 and Col2a1 during monoiodoacetate-induced OA in male rats. 30938133 2019
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE The results demonstrated that CH inhibited cell apoptosis, dose‑dependently reduced matrix metalloproteinase (MMP) 13, collagenase and IL‑6 expression, and increased collagen α‑1 (II) chain (COL2A1) expression in human osteoarthritis chondrocytes. 30535473 2019
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 Biomarker disease BEFREE Our study reveals novel mechanisms for the inhibition of chondrocyte hypertrophy by COL2A1 and suggests that the degradation and decrease in COL2A1 might initiate and promote osteoarthritis progression. 30854241 2019
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 GeneticVariation disease BEFREE When we analysed OA development in Col2a1-Cre;Runx1<sup>fl/fl</sup> and Runx1<sup>fl/fl</sup> mice by surgically inducing joint instability, Cartilage degradation and osteophyte formation of Col2a1-Cre;Runx1<sup>fl/fl</sup> joints was accelerated compared with joints in Runx1<sup>fl/fl</sup> animals 8 weeks after surgery. 31113964 2019
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE While H-PRP showed similar effects on expression of chondrogenic markers (Col2a1 and Sox9) as the negative control group (p > 0.05), OA-PRP decreased chondrocyte expression of Col2a1 and Sox-9 messenger RNA by 40% and 30%, respectively (Col2a1, p = 0.015; Sox9, p = 0.037). 31042308 2019
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 GeneticVariation disease BEFREE Follow-up with whole-exome sequencing analysis revealed a mutation c.2032G>A (p.Gly678Arg) in the COL2A1 gene (NCBI Reference Sequence: NM_001844.4), which co-segregated with the disease phenotype in this family, manifested by severe hip dysplasia and osteoarthritis. 30740902 2019
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 Biomarker disease BEFREE IL-1β stimulus determined a significant regulation of survival, apoptotic ratio, as well as of gene expression and serum levels of MMP-1,-3,-13 and Col2a1 in OA chondrocytes compared to baseline. 30316071 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE The expressions of FAS-AS1, MMP1, and MMP13 in osteoarthritis tissues increased significantly, while COL2A1 presented a low expression. 29863238 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 GeneticVariation disease BEFREE MSC-Exos increased chondrogenic genes Col2a1 (type II collagen alpha 1) and aggrecan, decreased hondrocyte hypertrophy markers MMP-13 (matrix metalloproteinase-13) and Runx2 (runt-related transcription factor 2) in chondrocytes isolated from OA model mice. 30324848 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE Following transfection with ds-miRNA-4784, Col2a1 mRNA expression levels increased by 63 and 126% compared with the levels prior to treatment in groups OA at week 4 and 8, respectively (P<0.01). 30542421 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 Biomarker disease BEFREE Thus, miR‑9 inhibits the expression level of MMP‑13, decreases its inhibitory effects on COL2A1, and therefore contributes to antagonizing OA. 29286096 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 Biomarker disease BEFREE <b>Results:</b> The results of ELISA (IL-1β and tumor necrosis factor-α), the histological evaluation (Mankin and OARSI score), western blotting [COL2A1, matrix metalloproteinase (MMP)-3, MMP-13, IL-1β, and nuclear factor-kappaB (NF-κB) p65], and immunohistochemistry (COL2A1, MMP-3, and MMP-13) indicated that oral CAR attenuated the development of T2DM-induced OA and suppressed the inflammatory response. 29928231 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE Compared with the normal group, the expression of ALK1, SMAD1, COL10A1 and MMP3 was higher in the OA groups, whereas the expression of COL2A1 was lower in the OA groups. 29753378 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE However, Wnt modulation increased COL2A1 and PRG4 transcripts, which are downregulated in chondrocytes in OA. 29415892 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE RESULTS Icariin treatment (mice in the ACLT + ICA group) significantly reduced degeneration of cartilage in OA with increased cartilage thickness, associated with increased expression of collagen type II alpha 1 (COL2A1), decreased chondrocyte hypertrophy, and decreased expression of collagen type X (ColX) and matrix metalloproteinase 13 (MMP13). 30244259 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE Patients with OA possessed high levels of lncRNA-CIR and MMP3 and low level of COL2A1. 30292414 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE Compared to control group, increasing levels of β-catenin and MMP-13 expression with reduction of miR-320 and COL2A1 expressions were observed in OA chondrocytes. 30280762 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 Biomarker disease BEFREE The purpose of the present study was to investigate the effect of visfatin and resistin on some miRNA (34a, 140, 146a, 155, 181a, let-7e), metalloproteinases (MMPs), and collagen type II alpha 1 chain (Col2a1) in human OA chondrocytes and in the T/C-28a2 cell line. 30563239 2018
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE Our results highlight the contribution of ELF3 to transcriptional regulation of COL2A1 and its potential role in OA disease, and uncover epigenetic mechanisms at play in the regulation of ELF3 and its downstream targets in articular chondrocytes. 27310669 2017
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 Biomarker disease BEFREE <i>Col2a1-CreER<sup>T2</sup>;Kdm6b<sup>f/f</sup></i> mice exhibited accelerated OA development at 8 and 12 weeks following surgical induction. 28314754 2017
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 Biomarker disease BEFREE Further, Wogonin exhibits potent chondroprotective potential by switching the signaling axis of matrix degradation from catabolic towards anabolic ends and inhibited the expression, production and activities of matrix degrading proteases including MMP-13, MMP-3, MMP-9, and ADAMTS-4 in OA chondrocytes, and blocked the release of s-GAG and COL2A1 in IL-1β-stimulated OA cartilage explants. 28237856 2017
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE Viral transduction of LOXL2 in OA chondrocytes increased the mRNA levels of chondroitin sulfate proteoglycan (CSPG4), aggrecan (ACAN), sex determining region Y-box containing gene 9 (SOX9), and COL2A1 but reduced the levels of extracellular matrix (ECM)-degrading enzymes matrix metalloproteinase (MMP)1, MMP3, and MMP13. 28764769 2017
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE In this present study, we used IL-1β (10 ng/ml) to mimic OA chondrocytes and we found that IL-1β stimulated chondrocytes caused the increasing expression of ADAMTS5 and MMP13, decreasing COL2A1 expression, which were in accord with OA chondrocytes changes. 28728848 2017
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1
0.500 AlteredExpression disease BEFREE Interestingly, SAHA rescued the COL2A1 and ACAN expression in OA chondrocytes that was down-regulated by IL-1β. 27555113 2016