|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis.
|
31546898 |
2019 |
|
TNFRSF11B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results verify that genetic variants of OPG contribute to knee OA susceptibility in the population of northern China.
|
30972968 |
2019 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Subgroup analysis indicated that plasma/serum OPG levels had no significant differences between RA patients and OA patients in Europe and Asian.
|
30188218 |
2019 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study is to explore the function of OPG in the postnatal maintenance and the occurring of osteoarthritis (OA) of temporomandibular joint (TMJ) in the rodent models.
|
30623241 |
2019 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
We describe oxidative mechanisms involving pro-inflammatory cytokines and oxidative species, advanced glycation end-products, sex hormones, microvascular dysfunction and osteoprotegerin, and their specific roles in potentially contributing to OA and cerebrovascular dysfunction.
|
29406252 |
2018 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Their expression was significantly reduced in patients with postmenopausal osteoporosis and osteoarthritis as compared to autopsy controls and significantly correlated with bone mineral density and several bone histomorphometry-derived parameters of bone quality and quantity as well as indicators of oxidative stress, RANK/RANKL/OPG system and angiogenesis.
|
30385847 |
2018 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Exposure of differentiated ASC to OA SF induced an increase in the expression of OPG, PTH1R, and MMP13 and a decrease in the expression of FGF2 in cell culture of the ACL group.
|
29156945 |
2018 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
At the same time, after the OA synoviocytes were treated with the VIP plasmid, the proliferation ability of OA synoviocytes was reduced, the protein expressions of Collagen II and OPG were remarkably up-regulated, and the protein expressions of TNF-α, IL-2, MMP-13 and ADAMTS-5 were significantly down-regulated.
|
29540226 |
2018 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression level of TNFRSF11B was markedly upregulated in the patients with OA, and the ectopic expression of miR‑145 was capable of suppressing the expression of TNFRSF11B.
|
27922673 |
2017 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The other factors of the rapid membrane signaling pathway, including extracellular signal-regulated protein kinases 1 (ERK1), osteopontin (OPG), alkaline phosphatase (ALP), and matrix metallopeptidase 13 (MMP13) were examined and were found to be significantly increased at 2 weeks post-shockwave treatment by qPCR in early OA of the knee.
|
29104478 |
2017 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An abnormal expression of OPG and RANKL has been described in osteoarthritis osteoblasts, which is responsible for abnormal bone remodeling and decreased mineralization.
|
28425564 |
2017 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Albeit that the role of the molecular pathway of osteoprotegerin has been studied in OA, we are the first to demonstrate that enhanced osteoprotegerin function could be a directly underlying cause.
|
24743232 |
2015 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among these proteins, the altered release of osteoprotegerin (decreased in OA) and periostin (increased in OA), both involved in bone remodelling processes, was verified in further analyses.
|
25383958 |
2014 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objective of the study was to determine whether cartilage expression of the bone regulating molecules receptor activator of nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG) varies between the different grades of osteoarthritis (OA).
|
21259010 |
2012 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We isolated human fibroblasts from RA, pyrophosphate arthropathy (PPA) and osteoarthritis (OA) patients and analyzed their RANKL/OPG expression profile and the capacity of their secreted factors to induce osteoclastogenesis.
|
22867712 |
2012 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although RANKL transcript abundance and the RANKL:OPG transcript ratio were significantly higher in patients with fractures than in those with osteoarthritis (RANKL: 0.76 ± 0.23 vs. 0.24 ± 0.08, p = 0.012; RANKL/OPG: 7.66 ± 2.49 vs. 0.92 ± 0.21, p = 0.002), there was no evidence for differential methylation across patient groups.
|
22207352 |
2012 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results showed OP specific negative correlations (IFN-γ with ITGB3, IFN-β1 with CTSK, tartrate resistant acid phosphatase (TRAP), CALCR, RANK, RANKL, IL-1α with CTSK, OPG, IL-17A with CALCR) and positive (TGF-β1 with CTSK, TRAP, RANK), and OA specific negative (IL-1α with osteoclast associated immunoglobulin-like receptor (OSCAR), TNF-α with RANK, RANKL, OPG) and positive (IL-6 with RANK, RANKL, OPG) correlations.
|
22380539 |
2012 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The published literature suggests that osteoprotegerin (OPG) and receptor activator of nuclear factor-kB ligand (RANKL) are essential for bone metabolism and correlate with osteoarthritis manifestation and progression.
|
22057548 |
2012 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Osteoprotegerin protein secretion in hOB cultures was higher in patients with osteoporosis than osteoarthritis.
|
21050847 |
2011 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
In human OA chondrocytes in culture, PGE(2) elicited a dose- and time-dependent increase in the synthesis of RANKL, the extent of which was greater than that of OPG.
|
20112374 |
2010 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, hOBs from hips with OP present a higher protein secretion of OPG, and higher RANKL and RANKL/OPG expression ratio in response to 1,25D and 1,25D+E2, than hOBs from OA women.
|
19073256 |
2009 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to clarify the significance of subchondral bone in the pathology of osteoarthritis (OA) by investigating the expression of inflammatory cytokines, proteases, and receptor activator of NF-kappaB ligand (RANKL)/receptor activator of NF-kappaB (RANK)/osteoprotegerin (OPG) involved in cartilage degeneration.
|
18528653 |
2008 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
RANKL:OPG ratios of messenger RNA (p<0.05) and protein level were high in pannus (2.06+/-0.73 and 2.2+/-0.65) compared to rheumatoid (0.62+/-0.13 and 1.31+/-0.69) and osteoarthritis (0.62+/-0.32 and 0.52+/-0.16) synovial membranes.
|
18565244 |
2008 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappaB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells.
|
18565252 |
2008 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effect of CS (200 mug/mL), GS (50 and 200 mug/mL), or both together on human OA subchondral bone osteoblasts, in the presence or absence of 1,25(OH)2D3 (vitamin D3) (50 nM), was determined on the bone biomarkers alkaline phosphatase and osteocalcin, on the expression (mRNA) and production (enzyme-linked immunosorbent assay) of bone remodelling factors OPG and RANKL, and on the pro-resorptive activity of these cells.
|
17996099 |
2007 |