Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3 		0.440 Biomarker disease HPO
Entrez Id: 1311
Gene Symbol: COMP
COMP 		0.440 Biomarker disease HPO
Entrez Id: 8200
Gene Symbol: GDF5
GDF5 		0.420 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 8200
Gene Symbol: GDF5
GDF5 		0.420 Biomarker disease HPO
Entrez Id: 1758
Gene Symbol: DMP1
DMP1 		0.300 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 2487
Gene Symbol: FRZB
FRZB 		0.140 Biomarker disease HPO
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1 		0.130 Biomarker disease HPO
Entrez Id: 176
Gene Symbol: ACAN
ACAN 		0.110 Biomarker disease HPO
Entrez Id: 6399
Gene Symbol: TRAPPC2
TRAPPC2 		0.100 Biomarker disease HPO
Entrez Id: 59341
Gene Symbol: TRPV4
TRPV4 		0.100 Biomarker disease HPO
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.100 Biomarker disease HPO
Entrez Id: 1186
Gene Symbol: CLCN7
CLCN7 		0.100 Biomarker disease HPO
Entrez Id: 1297
Gene Symbol: COL9A1
COL9A1 		0.020 GeneticVariation disease BEFREE COL9A1 may therefore be a susceptibility locus for female hip OA. 10788539 2000
Entrez Id: 1302
Gene Symbol: COL11A2
COL11A2 		0.010 Biomarker disease BEFREE In addition, there was weak evidence of linkage to HLA/COL11A2 (6p21.3) in female hip OA with a corrected P-value of 0.016. 10788539 2000
Entrez Id: 1280
Gene Symbol: COL2A1
COL2A1 		0.130 GeneticVariation disease BEFREE Haplotype analysis showed significant association between a specific haplotype of COL2A1 and hip OA (p = 0.024; OR = 1.30). 12096843 2002
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.050 Biomarker disease BEFREE The IL-1 ligand cluster encodes for susceptibility to knee OA but not to hip OA, highlighting the genetic heterogeneity of this common, complex disease. 12115182 2002
Entrez Id: 3552
Gene Symbol: IL1A
IL1A 		0.030 Biomarker disease BEFREE The IL-1 ligand cluster encodes for susceptibility to knee OA but not to hip OA, highlighting the genetic heterogeneity of this common, complex disease. 12115182 2002
Entrez Id: 4146
Gene Symbol: MATN1
MATN1 		0.010 GeneticVariation disease BEFREE We compared genotype frequencies of the MATN-1 gene (1p35) in patients with OA and controls to determine if there is any association between the MATN-1 genotype and OA. 12175111 2003
Entrez Id: 2487
Gene Symbol: FRZB
FRZB 		0.140 GeneticVariation disease BEFREE Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. 15210948 2004
Entrez Id: 2487
Gene Symbol: FRZB
FRZB 		0.140 GeneticVariation disease LHGDN Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. 15210948 2004
Entrez Id: 7130
Gene Symbol: TNFAIP6
TNFAIP6 		0.010 GeneticVariation disease BEFREE However, genotyping showed lack of association for a nonsynonymous single-nucleotide polymorphism in tumor necrosis factor alpha-induced protein 6, whereas a single-nucleotide polymorphism in FRZB resulting in an Arg324Gly substitution at the carboxyl terminus was associated with hip OA in the female probands (P = 0.04). 15210948 2004
Entrez Id: 3566
Gene Symbol: IL4R
IL4R 		0.010 GeneticVariation disease BEFREE Our data suggest that functional variants within the IL4R gene predispose to hip OA in Caucasian females. 14745651 2004
Entrez Id: 3566
Gene Symbol: IL4R
IL4R 		0.010 GeneticVariation disease LHGDN Our data suggest that functional variants within the IL4R gene predispose to hip OA in Caucasian females. 14745651 2004
Entrez Id: 2487
Gene Symbol: FRZB
FRZB 		0.140 GeneticVariation disease BEFREE A UK group reported an association of the FRZB gene with hip osteoarthritis in females. 16093844 2005
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.060 GeneticVariation disease BEFREE The distribution of IL-6 genotypes in (1) patients with hip OA: 33 GG, 30 GC, 12 CC and (2) control subjects: 34 GG, 40 GC, 33 CC. 16198603 2005