Using several mutant mouse strains, immunoblotting, and microcomputed tomography (micro-CT), we demonstrate that absent in melanoma 2 (AIM2), receptor-interacting serine/threonine protein kinase 3 (RIPK3), and caspase recruitment domain-containing protein 9 (CARD9) are each dispensable for osteomyelitis induction in <i>Pstpip2<sup>cmo</sup></i> mice, whereas genetic deletion of <i>Syk</i> completely abrogates the disease phenotype.