Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 Biomarker disease BEFREE Also, an important aspect is the influence of PPARs in bone metabolism; the main periodontitis symptom is bone loss and PPARγ activation that can downregulate the bone resorption in experimental periodontitis, PPARγ-coated titanium dental implant surfaces could carry the antiinflammatory gene and restrain inflammation. 28678155 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 GeneticVariation disease BEFREE The treatment of type 2 diabetes with full peroxisome proliferator-activated receptor gamma (PPARγ) agonists improves insulin sensitivity, but is associated with weight gain, heart failure, peripheral oedema and bone loss. 27631136 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 Biomarker disease BEFREE In this study, we detected local and systemic bone loss in trabecular bone by micro-computed tomography (micro-CT) and measurement of peroxisome proliferator-activated receptor gamma (PPARγ) and runt-related transcription factor 2 (RUNX2) expression in BMSCs using real-time polymerase chain reaction and western blotting. 28320453 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 GeneticVariation disease BEFREE Pioglitazone, a PPAR-γ agonist associated with bone loss and risk of fracture in type 2 diabetes mellitus patients. 28810524 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 Biomarker disease BEFREE For instance, thiazolidinediones increases the bone loss and risk of fracture possibly through PPARγ activation in bone marrow cells and hamper osteoblastogenesis via decreasing Runx2 transcription factor, IGF-1 and Wnt signalling pathways. 29132091 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 Biomarker disease BEFREE The results indicated that miR-130a promotes osteoblastic differentiation of BMSC by negatively regulating Smurf2 expression and suppresses adipogenic differentiation of BMSC by targeting the PPARγ, and supply a new target for clinical therapy of age-related bone loss. 31557368 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 AlteredExpression disease BEFREE Recently reported 15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> (15d-PGJ<sub>2</sub>) is an endogenous ligand of peroxisome proliferator-activated receptor-gamma, with an inhibitory activity on bone loss. 31760999 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 AlteredExpression disease BEFREE PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss. 20519122 2010
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 Biomarker disease HPO
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 Biomarker disease BEFREE The PPAR-γ antagonist T007 inhibits RANKL-induced osteoclastogenesis and counteracts OVX-induced bone loss in mice. 31655621 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 Biomarker disease BEFREE The aim of this study is to determine if PPARγ inhibition can prevent ovariectomy-induced BMAT increase and bone loss in C3H/HeJ mice. 30457914 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 Biomarker disease BEFREE Iguratimod prevents ovariectomy‑induced bone loss and suppresses osteoclastogenesis via inhibition of peroxisome proliferator‑activated receptor‑γ. 28983607 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.200 Biomarker disease BEFREE It is known that PPARγ activation induces bone loss. 31606379 2019