Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE In multivariable analysis, only higher body mass index (OR 0.6 per 5kg/m<sup>2</sup>, 95% CI: 0.4-0.7) and nonwhite race compared to white (OR 0.5, 95% CI: 0.2-0.9) were protective for bone loss while older age (OR 1.5 per 10years, 95% CI: 1.1-2.1) and selective estrogen receptor modulator use (3.1, 95% CI: 1.2-10.1) were associated with increased odds of bone loss. 29422346 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE Polymorphisms in the CYP19A1 (aromatase) gene influence disease-free survival and bone loss in patients taking aromatase inhibitors (AIs) for estrogen receptor-positive (ER+) breast cancers. 26049585 2015
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE Previous studies have revealed that ICA exerted a protective effect against bone loss and increased bone regeneration; however, the association between ICA and estrogen receptor (ER) signaling remains unclear. 30066871 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Thus, a male carrying homozygous mutations in the ER-alpha gene and two males with homozygous mutations in the aromatase gene had osteopenia, unfused epiphyses, and elevated indices of bone turnover. 11730247 2001
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE Estrogen and the estrogen receptor (ER) play a central role in bone metabolism as illustrated by the loss of bone mass after menopause and the osteopenia in individuals with defect aromatase or ER. 11092403 2000
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE There was a significant association between a common haplotype "px", defined by the PvuII and XbaI restriction fragment length polymorphisms within intron 1 of the ESR1 gene, and femoral neck bone loss in postmenopausal women who had not received hormone replacement therapy (n = 945; p = 0.009). 15744038 2005
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE Osteoclast-specific HIF1α inactivation antagonized bone loss in Ovx mice and osteoclast-specific estrogen receptor alpha deficient mice, both models of estrogen-deficient osteoporosis. 24023068 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 AlteredExpression disease BEFREE Accordingly, the rate of bone loss is accelerated in ovariectomized, estrogen-deficient gal-8 Tg mice, whereas gal-8 KO mice, having low levels of ESR1, are refractory to ovariectomy. 29259034 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE Thus, Mongolian echinops reduced bone loss and delayed the occurrence and development of osteoporosis, and increased ERα, ERβ, p-AKT, and P-ERK in BMSCs. 29794404 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE However, the ER-alpha (but not ER-beta) genotypes did modulate the previously described relationships between BMD or rates of bone loss and bioavailable estradiol (E(2)) levels in these men. 15070949 2004
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE We have previously reported that PvuII polymorphism of the estrogen receptor-alpha (ER alpha) gene is associated with bone loss rate, fracture risk, and response to hormone replacement therapy (HRT) in early postmenopausal Finnish women. 12014437 2002
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects against estrogen-deficient bone loss. 28768649 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE We conclude that subjects with the ER PvuII genotypes PP and Pp may have a greater risk of relatively fast bone loss after menopause than those with the pp genotype and that they may preferentially derive benefit from HRT. 10703934 2000
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE Dehydrodiconiferyl Alcohol Inhibits Osteoclast Differentiation and Ovariectomy-Induced Bone Loss through Acting as an Estrogen Receptor Agonist. 29869503 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease HPO
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 AlteredExpression disease BEFREE Inactivation of estrogen receptor α in bone-forming cells induces bone loss in female mice. 23073829 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE The ERA polymorphism was significantly associated with bone loss from the distal forearm (P = 0.04) but not with bone loss from the spine. 16735942 2006
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Estrogen receptor alpha CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women. 17896124 2008
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE The estrogen receptor (ER) mixed agonists tamoxifen and raloxifene have been shown to protect against bone loss in ovariectomized rats. 9275080 1997
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE We therefore determined (i) whether heavy alcohol consumption (35% caloric intake) influences bone in sexually mature ovx rats with established cancellous osteopenia and (ii) whether ICI 182,780 (ICI), a potent estrogen receptor signaling antagonist, alters the skeletal response to alcohol. 31479513 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE Estrogen receptor alpha polymorphism as a genetic marker for bone loss, vertebral fractures and susceptibility to estrogen. 11886765 2002
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE In conclusion, we could not demonstrate any major effect of the ER gene polymorphisms on BMD or rate of bone loss in healthy postmenopausal Danish women. 10678404 2000
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 AlteredExpression disease BEFREE Bone loss in these patients may be due to deficient ER-alpha protein expression. 10773580 2000
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 GeneticVariation disease BEFREE These results indicate that the PvuII and the XbaI polymorphisms of ESR1 gene are associated with bone mineral density in premenopausal women with GD and may help to estimate the risk of bone loss particularly at lumbar spine. 21423915 2011
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE These results demonstrate that the prevention from the ovariectomy-induced bone loss by estrogen is mediated by ER pathways and that the maintenance of BMD before ovariectomy might be compensated by other mechanisms distinct from ERalpha and ERbeta pathways. 10806217 2000