Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 AlteredExpression disease BEFREE Bone loss in these patients may be due to deficient ER-alpha protein expression. 10773580 2000
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE These results demonstrate that the prevention from the ovariectomy-induced bone loss by estrogen is mediated by ER pathways and that the maintenance of BMD before ovariectomy might be compensated by other mechanisms distinct from ERalpha and ERbeta pathways. 10806217 2000
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease BEFREE The estrogen receptor (ER) mixed agonists tamoxifen and raloxifene have been shown to protect against bone loss in ovariectomized rats. 9275080 1997
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.500 Biomarker disease HPO
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease BEFREE To test a model that assesses the relationship between hypothalamic atrophy and bone loss in Alzheimer's disease (AD) and potential mediation through neural (leptin) and neurohumoral (insulin-like growth factor -1, IGF-1) mechanisms. 30593432 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease BEFREE <b>Results:</b> While the rise in Thyroid-stimulating hormone (TSH) levels has a protective role on bone mass, the decline of estrogen, testosterone, Insulin-like growth factor 1 (IGF1), and vitamin D and the rise of cortisol, parathyroid hormone, and follicle-stimulating hormone (FSH) favor bone loss in the elderly. 31581477 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 GeneticVariation disease BEFREE This study investigated whether the effects of dietary acid load (DAL) on bone loss in postmenopausal Chinese women were moderated by the insulin-like growth factor-1 (IGF-1) single nucleotide polymorphism, a known gene that plays a role in the regulation of bone formation and bone remodeling. 30018240 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease BEFREE Although bone loss in IBD is multifactorial, the altered sensitivity and secretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in IBD is understood to be a critical contributing mechanism. 29343614 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease BEFREE Both BMD and IGF-1 were significantly in low children with spastic CP; IGF-1 negatively correlates with the severity of osteopenia in children with spastic. 28236062 2017
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease BEFREE Excess GH production in tissues did not protect from trabecular bone loss in response to reductions in serum IGF-1 (in bGH/ALSKO or bGH mice treated with siRNAs). 28475811 2017
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 AlteredExpression disease BEFREE These results indicate that high local levels of hGH or IGF-I in the bone marrow microenvironment enhanced resorption, which is consistent with previous findings in transgenic mice with targeted bone IGF-I expression showing that high local IGF-I expression increased bone remodeling, favoring a net bone loss. 21322098 2011
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease BEFREE In conclusion, bone loss continues in adult thalassaemia patients and is associated with increased bone resorption and decreased IGF-1. 11122154 2000
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Therapeutic disease CTD_human Advanced liver cirrhosis is associated with osteopenia and also with low serum levels of IGF-I. 11014614 2000
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease HPO
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.440 Biomarker disease BEFREE To determine whether circulating levels of two matrix metalloproteinases, MMP-2 and MMP-9, are associated with loss of alveolar bone density (ABD) or height (ABH), or with progression of periodontitis (relative clinical attachment level [RCAL]), among postmenopausal women with local and systemic bone loss. 31032961 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.440 Biomarker disease BEFREE However, by using MMP2 short hairpin RNA, we demonstrate that the αvβ6 effect on bone loss is due to upregulation of soluble MMP2 by the cancer cells, not due to changes in tumor growth rate. 24385215 2014
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.440 Biomarker disease CTD_human Recessive inactivating mutations in human matrix metalloproteinase 2 (MMP2, gelatinase A) are associated with syndromes that include abnormal facial appearance, short stature, and severe bone loss. 17440987 2007
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.440 Biomarker disease BEFREE The apparent lack of a murine model [Itoh, T., Ikeda, T., Gomi, H., Nakao, S., Suzuki, T. and Itohara, S. (1997) Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice.J. Biol.Chem., 272, 22389-22392.] has hindered studies on disease pathogenesis and, more fundamentally, in addressing the paradox of how functional loss of a single proteolytic enzyme results in an apparent increase in bone loss. 17400654 2007
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.440 GeneticVariation disease BEFREE Recessive inactivating mutations in human matrix metalloproteinase 2 (MMP2, gelatinase A) are associated with syndromes that include abnormal facial appearance, short stature, and severe bone loss. 17440987 2007
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.440 Biomarker disease HPO
Entrez Id: 80169
Gene Symbol: CTC1
CTC1
0.400 Biomarker disease CTD_human Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus. 22267198 2012
Entrez Id: 80169
Gene Symbol: CTC1
CTC1
0.400 Biomarker disease HPO
Entrez Id: 8884
Gene Symbol: SLC5A6
SLC5A6
0.300 Biomarker disease GENOMICS_ENGLAND Biotin and pantothenic acid oversupplementation to conditional SLC5A6 KO mice prevents the development of intestinal mucosal abnormalities and growth defects. 29669219 2018
Entrez Id: 162466
Gene Symbol: PHOSPHO1
PHOSPHO1
0.300 Biomarker disease CTD_human Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi t1 Double-Knockout Mice. 26773408 2016
Entrez Id: 249
Gene Symbol: ALPL
ALPL
0.300 Biomarker disease CTD_human Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi t1 Double-Knockout Mice. 26773408 2016