| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Here, we used conditional Dkk1 knock-out mice to determine the role of Dkk1 produced by osteolineage cells in the development of arthritis and GC-induced bone loss. | 30779862 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | A rat apical periodontitis model was used to further evaluate the function of Dickkopf-1 in relation to bone loss. | 29216526 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Estrogen-deficient ovariectomized rats showed significant mandibular bone loss that was reversed by systemic administration of sclerostin antibody (SAB) alone and in combination with DKK1 antibody (DAB). | 29617179 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Wnt/β-catenin signalling components was shown to affect bone cells function including chondrocytes.Secreted Dkk1, a potent osteogenesis inhibiting factor mediates bone loss in diseased bones by suppressing the biological actions of Wnt proteins. | 27580425 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Transgenic (TG) mice overexpressing human IL-32γ showed reduced bone loss with advancing age, increased bone formation, and high osteogenic capacity of osteoblast compared to wild-type (WT) mice through the upregulation of miR-29a, which caused a reduction of Dickkopf-1 (DKK1) expression. | 28079119 | 2017 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Five tag single nucleotide polymorphisms of DKK1 were analyzed in 639 Chinese postmenopausal women with osteoporosis or osteopenia. | 26780085 | 2016 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | DKK-1 is a regulator of bone mass with increased expression linked to osteopenia and decreased expression to high bone mass. | 21435697 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | These data indicate that Dkk1 may directly influence bone formation and suggest that osteopenia develops in mice over-expressing Dkk1 at least in part due to diminished bone formation resulting from reduced osteoblast numbers. | 16730481 | 2006 |