Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease BEFREE To test a model that assesses the relationship between hypothalamic atrophy and bone loss in Alzheimer's disease (AD) and potential mediation through neural (leptin) and neurohumoral (insulin-like growth factor -1, IGF-1) mechanisms. 30593432 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease BEFREE <b>Results:</b> While the rise in Thyroid-stimulating hormone (TSH) levels has a protective role on bone mass, the decline of estrogen, testosterone, Insulin-like growth factor 1 (IGF1), and vitamin D and the rise of cortisol, parathyroid hormone, and follicle-stimulating hormone (FSH) favor bone loss in the elderly. 31581477 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 GeneticVariation disease BEFREE This study investigated whether the effects of dietary acid load (DAL) on bone loss in postmenopausal Chinese women were moderated by the insulin-like growth factor-1 (IGF-1) single nucleotide polymorphism, a known gene that plays a role in the regulation of bone formation and bone remodeling. 30018240 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease BEFREE Although bone loss in IBD is multifactorial, the altered sensitivity and secretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in IBD is understood to be a critical contributing mechanism. 29343614 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease BEFREE Both BMD and IGF-1 were significantly in low children with spastic CP; IGF-1 negatively correlates with the severity of osteopenia in children with spastic. 28236062 2017
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease BEFREE Excess GH production in tissues did not protect from trabecular bone loss in response to reductions in serum IGF-1 (in bGH/ALSKO or bGH mice treated with siRNAs). 28475811 2017
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 AlteredExpression disease BEFREE These results indicate that high local levels of hGH or IGF-I in the bone marrow microenvironment enhanced resorption, which is consistent with previous findings in transgenic mice with targeted bone IGF-I expression showing that high local IGF-I expression increased bone remodeling, favoring a net bone loss. 21322098 2011
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease BEFREE In conclusion, bone loss continues in adult thalassaemia patients and is associated with increased bone resorption and decreased IGF-1. 11122154 2000
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Therapeutic disease CTD_human Advanced liver cirrhosis is associated with osteopenia and also with low serum levels of IGF-I. 11014614 2000
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.480 Biomarker disease HPO