Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4041
Gene Symbol: LRP5
LRP5
0.140 GeneticVariation disease BEFREE The aim of the study was to evaluate the frequency of genotypes and alleles of single nucleotide polymorphism (SNP) rs4988321 and rs312009 of LRP5 in Polish postmenopausal women with osteopenia (n = 109) and osteoporosis (n = 333). 29963786 2019
Entrez Id: 4041
Gene Symbol: LRP5
LRP5
0.140 GeneticVariation disease BEFREE Both disuse stimuli induced significant bone loss in WT mice, but Lrp5 A214V and G171V were partially or fully protected from the bone loss that normally results from disuse. 26554834 2015
Entrez Id: 4041
Gene Symbol: LRP5
LRP5
0.140 GeneticVariation disease BEFREE In addition to the ocular features, LRP5 mutations can cause osteopenia and osteoporosis. 25323851 2015
Entrez Id: 4041
Gene Symbol: LRP5
LRP5
0.140 GeneticVariation disease BEFREE A non-synonymous SNP in the LRP5 gene was associated with decreased bone mineral density (rs3736228, p=6.3x10(-12) for lumbar spine and p=1.9x10(-4) for femoral neck) and an increased risk of both osteoporotic fractures (odds ratio [OR] 1.3, 95% CI 1.09-1.52, p=0.002) and osteoporosis (OR 1.3, 1.08-1.63, p=0.008). 18455228 2008
Entrez Id: 4041
Gene Symbol: LRP5
LRP5
0.140 Biomarker disease HPO