Recently, we and others showed that the relative abundance of a specific vessel subtype, strongly positive for CD31 and Endomucin (CD31hiEmcnhi), is associated with bone formation and bone loss, and platelet-derived growth factor-BB (PDGF-BB) secreted by preosteoclasts induces the formation of the specific vessels and thereby stimulates osteogenesis.
Here we tested whether the type H vessel, which was recently identified as strongly positive for CD31 and Endomucin (CD31<sup>hi</sup>Emcn<sup>hi</sup>) in mice, is an important indicator of aging and osteopenia in human subjects.