Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		0.400 Therapeutic disease RGD [The expression of estrogen receptor alpha and beta in the intervention of different estrogens in rat bone metabolism]. 16955786 2006
Entrez Id: 367
Gene Symbol: AR
AR 		0.390 Therapeutic disease RGD Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis. 14600402 2003
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.300 Therapeutic disease RGD Our study was designed to investigate whether resveratrol, an agonist of SIRT1, could have favorable effect on osteoporosis and to explore the underlying mechanisms. 25377437 2014
Entrez Id: 632
Gene Symbol: BGLAP
BGLAP 		0.300 Biomarker disease RGD Protective effects of Polygonatum sibiricum polysaccharide on ovariectomy-induced bone loss in rats. 21550389 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.300 Therapeutic disease RGD Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells. 22555620 2013
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Biomarker disease RGD Propranolol Prevents Osteoporosis and up-regulates Leptin in Ovariectomized Rats. 24250662 2013
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.300 Therapeutic disease RGD Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus. 12609558 2003
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.250 Biomarker disease RGD Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats. 22997530 2012
Entrez Id: 2688
Gene Symbol: GH1
GH1 		0.250 Biomarker disease RGD Diabetic bone disease. Low turnover osteoporosis related to decreased IGF-I production. 1466160 1992
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.230 Biomarker disease RGD Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats. 19590507 2009
Entrez Id: 8660
Gene Symbol: IRS2
IRS2 		0.220 Biomarker disease RGD Altered gene expression involved in insulin signaling pathway in type II diabetic osteoporosis rats model. 22820932 2013
Entrez Id: 177
Gene Symbol: AGER
AGER 		0.220 Biomarker disease RGD High cholesterol diet increases osteoporosis risk via inhibiting bone formation in rats. 22036861 2011
Entrez Id: 596
Gene Symbol: BCL2
BCL2 		0.210 Therapeutic disease RGD When compared with the osteoporosis group (p < 0.05), alendronate (30 days), EGb1 and EGb2 (20/30 days) increased the Bcl-2 expression; EGb2 and alendronate (20 days) EGb1 and EGb2 (30 days) reduced the Bax expression; and EGb1 and EGb2 (20/30 days) reduced the X-ray density. 22648569 2013
Entrez Id: 2690
Gene Symbol: GHR
GHR 		0.210 Biomarker disease RGD Etiopathogenesis of hepatic osteodystrophy in Wistar rats with cholestatic liver disease. 19424739 2009
Entrez Id: 3481
Gene Symbol: IGF2
IGF2 		0.210 Therapeutic disease RGD These results demonstrate that short-term administration of the IGF-II/IGFBP-2 complex can prevent loss of BMD associated with disuse osteoporosis and stimulate bone formation in adult rats. 12162999 2002
Entrez Id: 2690
Gene Symbol: GHR
GHR 		0.210 Therapeutic disease RGD Growth hormone treatment prevents osteoporosis in uremic rats. 17647196 2007
Entrez Id: 1432
Gene Symbol: MAPK14
MAPK14 		0.210 Therapeutic disease RGD Prevention of trabecular bone loss induced by estrogen deficiency by a selective p38alpha inhibitor. 18442314 2008
Entrez Id: 581
Gene Symbol: BAX
BAX 		0.210 Therapeutic disease RGD The effect of the Ginkgo biloba extract in the expression of Bax, Bcl-2 and bone mineral content of Wistar rats with glucocorticoid-induced osteoporosis. 22648569 2013
Entrez Id: 4609
Gene Symbol: MYC
MYC 		0.210 Biomarker disease RGD Effects of pulsed electromagnetic fields on bone mass and Wnt/β-catenin signaling pathway in ovariectomized rats. 22704852 2012
Entrez Id: 5111
Gene Symbol: PCNA
PCNA 		0.210 Biomarker disease RGD Proliferation and differentiation of osteoblasts from the mandible of osteoporotic rats. 22550338 2012
Entrez Id: 3667
Gene Symbol: IRS1
IRS1 		0.200 Biomarker disease RGD Altered gene expression involved in insulin signaling pathway in type II diabetic osteoporosis rats model. 22820932 2013
Entrez Id: 5734
Gene Symbol: PTGER4
PTGER4 		0.200 Therapeutic disease RGD Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats. 16442794 2006
Entrez Id: 1834
Gene Symbol: DSPP
DSPP 		0.200 Biomarker disease RGD Estrogen deficiency reduces the dentinogenic capacity of rat lower incisors. 23974864 2014
Entrez Id: 4041
Gene Symbol: LRP5
LRP5 		0.900 Biomarker disease HPO
Entrez Id: 7471
Gene Symbol: WNT1
WNT1 		0.700 Biomarker disease HPO