Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Besides that, in our review, we briefly introduced the current application of several natural compounds for treating RANKL-mediated osteoclastic activation by modulating the RANKL signaling pathway and their effects on the treatment and prevention of osteoporosis, osteoarthritis and rheumatoid arthritis. 31566133 2020
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Receptor activator of nuclear factor-κB ligand (RANKL) plays a role in the pathology of osteoporosis, and anti-RANKL antibody has been used in the treatment of osteoporosis. 31790783 2020
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Collectively, Asperpyrone A attenuates RANKL-induced osteoclast formation via suppressing NFATc1, Ca<sup>2+</sup> signalling and oxidative stress, as well as MAPK and NF-κB signalling pathways, indicating that this compound may become a potential candidate drug for the prevention or treatment of osteoporosis. 31612613 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Beneficial effects of Cuscuta chinensis extract on glucocorticoid-induced osteoporosis through modulation of RANKL/OPG signals. 31826180 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE The receptor activator of nuclear factor-kappa B ligand (RANKL)-induced nuclear factor-kappa B (NF-κB) signaling pathway plays essential roles in osteoclast differentiation and may serve as an attractive target for the development of therapeutics for osteoporosis. 30978650 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 GeneticVariation disease BEFREE In summary, the rs3018362 polymorphism in the RANK gene seems to be associated with osteoporosis of the lumbar spine while the RANKL rs12585014 is not, although more studies are needed to confirm these results. 31126201 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Denosumab, a RANKL inhibitor, reduced the risk of vertebral, hip, and nonvertebral fractures in the Fracture REduction Evaluation of Denosumab in Osteoporosis every 6 Months (FREEDOM) trial of postmenopausal women with osteoporosis compared with placebo. 30601581 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Loureirin B suppresses RANKL-induced osteoclastogenesis and ovariectomized osteoporosis via attenuating NFATc1 and ROS activities. 31367247 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Vitamin B5 inhibit RANKL induced osteoclastogenesis and ovariectomy induced osteoporosis by scavenging ROS generation. 31497217 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE The effects on osteoclasts and anti-osteoporosis functions were investigated in a RANKL-induced cell model and ovariectomized (OVX) mice. 31576127 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 AlteredExpression disease BEFREE The aim of the present study was to investigate the antiosteoclastogenic effects of black rice (<i>Oryza sativa L.</i>) fermented with <i>Lactobacillus casei</i> (LAB) in RANKL-induced RAW macrophage cells and its antiosteoporosis activity against ovariectomy-induced osteoporosis in rats. 30911544 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Cajaninstilbene acid inhibits osteoporosis through suppressing osteoclast formation and RANKL-induced signaling pathways. 30515822 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE We also found that treatment with fangchinoline attenuated the altered expressions of LC3, Bcl-2, caspase-3, BMP2, Beclin-1, ATG-5, RUNX-2, and RANKL protein in the prednisolone-induced osteoporosis rats. 30632520 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Disulfiram suppressed ethanol promoted RANKL-induced osteoclastogenesis in vitro and ethanol-induced osteoporosis in vivo via ALDH1A1-NFATc1 axis. 31596733 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE In conclusion, these results demonstrated that DAC suppressed RANKL-induced inflammation and osteoclastogenesis and therefore it can be used as a potential treatment for osteoporosis, arthritis, osteolysis, and aseptic loosening of artificial prostheses. 31231214 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE LncRNA Bmncr inhibits RANKL-induced osteoclast differentiation, thus alleviating the progression of osteoporosis. 31773670 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 AlteredExpression disease BEFREE Loss of bone in inflammatory disease, metastasizing tumors and osteoporosis is due to increased RANKL expression and enhanced osteoclast formation. 31763801 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Vitamin C reduced the expression of osteoclast differentiation genes, such as receptor activator of nuclear factor kappa-B, receptor activator of nuclear factor kappa-B ligand, tartrate-resistant acid phosphatase, and cathepsin K. This study is the first to show that vitamin C can inhibit osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through the activation of wingless-type MMTV integration site family/β-catenin/activating transcription factor 4 signaling, which is achieved through the serine/threonine kinase and mitogen-activated protein kinase signaling pathways. 30818817 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Blockade of receptor activator of nuclear factor kappa-B ligand (RANKL) improves osteoporosis, but might also improve glucose tolerance through reduction of hepatic insulin resistance. 31764838 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE In this study, we investigated the effects of BP on ovariectomy-induced osteoporosis and receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis in vivo and in vitro, and explored the underlying mechanism. 30579598 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Antiresorptive drugs, such as the bisphosphonates and the RANKL inhibitor denosumab, are currently the most widely used osteoporosis medications. 30657216 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 AlteredExpression disease BEFREE Sex-determining region Y (SRY) attributes to gender differences in RANKL expression and incidence of osteoporosis. 31409771 2019
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Denosumab (DNM) is a fully human monoclonal antibody against the receptor activator of nuclear factor kappa-B ligand (RANKL) that has been licensed for the treatment of different types of osteoporosis. 30381400 2018
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 Biomarker disease BEFREE Denosumab is a monoclonal RANKL antibody, which was originally introduced for the treatment of osteoporosis and bone metastases from solid tumors, but more recently has been used for treatment of giant cell tumor of bone (GCTB). 30778015 2018
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
0.600 AlteredExpression disease BEFREE This paper contrasted their anti-osteoporosis activity from the perspective of their affinity to OPG/RANKL protein targets. 30036771 2018