Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5981
Gene Symbol: RFC1
RFC1
0.340 Biomarker disease CTD_human Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. 19159907 2009
Entrez Id: 5981
Gene Symbol: RFC1
RFC1
0.340 GeneticVariation disease BEFREE Acquired alterations of the RFC gene have been associated with resistance to MTX in cancer cell lines and primary osteosarcomas. 18028428 2008
Entrez Id: 5981
Gene Symbol: RFC1
RFC1
0.340 Biomarker disease BEFREE To evaluate the impact of dihydrofolate reductase (DHFR) and reduced folate carrier (RFC) genes on methotrexate (MTX) resistance in osteosarcoma cells in relation to retinoblastoma (RB1) gene status. 14679136 2004
Entrez Id: 5981
Gene Symbol: RFC1
RFC1
0.340 Biomarker disease BEFREE Further analyses of DHFR, MLL, MYC, and RFC gene status in four additional human OS cell lines revealed that only gain of DHFR and MLL were associated with an inherent lower sensitivity to MTX. 14582536 2003
Entrez Id: 5981
Gene Symbol: RFC1
RFC1
0.340 GeneticVariation disease BEFREE The purpose of this study was to investigate sequence alterations in the RFC gene in osteosarcoma tumor samples. 12576457 2003