XRCC3Thr241Met gene polymorphism was associated with osteosarcoma risk, but XRCC3 Thr241Met CC genotype was not associated with Enneking stage, tumor location, and tumor metastasis.
In conclusion, we found that XRCC3Thr241Met gene polymorphism was associated with increased risk of osteosarcoma in codominant, dominant and recessive models.