Gene: TNFRSF11A ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8792
Gene Symbol: TNFRSF11A
TNFRSF11A 		0.360 AlteredExpression disease BEFREE The analysis of RANKL, RANK and osteoprotegerin (OPG) expressions in biopsies of a cohort of patients revealed that while RANK expression in osteosarcoma cells was not significantly different between patients with or without metastases at the time of diagnosis, the OPG/RANK ratio decreased significantly. 30355966 2018
Entrez Id: 8792
Gene Symbol: TNFRSF11A
TNFRSF11A 		0.360 Biomarker disease BEFREE Thus, RANK was identified as a negative prognostic factor of osteosarcoma survival. 28587351 2017
Entrez Id: 8792
Gene Symbol: TNFRSF11A
TNFRSF11A 		0.360 Biomarker disease LHGDN Receptor activator of nuclear factor-kappaB ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells. 17982618 2007
Entrez Id: 8792
Gene Symbol: TNFRSF11A
TNFRSF11A 		0.360 AlteredExpression disease BEFREE This is the first report describing a functional RANK expressed on osteosarcoma cells, as shown by its ability to induce signal transduction pathways and biological activity when stimulated by RANKL. 16328004 2006
Entrez Id: 8792
Gene Symbol: TNFRSF11A
TNFRSF11A 		0.360 AlteredExpression disease LHGDN This is the first report describing a functional RANK expressed on osteosarcoma cells, as shown by its ability to induce signal transduction pathways and biological activity when stimulated by RANKL. 16328004 2006
Entrez Id: 8792
Gene Symbol: TNFRSF11A
TNFRSF11A 		0.360 Biomarker disease BEFREE Previous analysis of tumor-specific constitutional LOH had identified a putative tumor-suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. 12673693 2003
Entrez Id: 8792
Gene Symbol: TNFRSF11A
TNFRSF11A 		0.360 Biomarker disease GENOMICS_ENGLAND Previous analysis of tumor-specific constitutional LOH had identified a putative tumor-suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. 12673693 2003
Entrez Id: 8792
Gene Symbol: TNFRSF11A
TNFRSF11A 		0.360 Biomarker disease GENOMICS_ENGLAND These data indicate that TNFRSF11A mutations contribute neither to the vast majority of cases of sporadic or familial PDB, nor to the development of osteosarcoma. 11351498 2001
Entrez Id: 8792
Gene Symbol: TNFRSF11A
TNFRSF11A 		0.360 GeneticVariation disease BEFREE These data indicate that TNFRSF11A mutations contribute neither to the vast majority of cases of sporadic or familial PDB, nor to the development of osteosarcoma. 11351498 2001