Gene: BRCA1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 Biomarker disease HPO
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE Risk-reducing salpingo-oophorectomy (RRSO) is recommended for BRCA1/2 mutation carriers because of their increased risk of ovarian carcinoma. 29315498 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE Women with an existing breast carcinoma diagnosis who are found to carry a BRCA1/2 mutation have a substantial risk of developing both a contralateral breast carcinoma and ovarian carcinoma. 11900216 2002
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE One mutation and three rare variants were identified in four women with no family history of breast or ovarian carcinoma whereas all women with affected first-degree relatives did not harbor BRCA1 mutations. 10951344 2000
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE Germ-line mutations in the BRCA1 and BRCA2 genes confer a predisposition to breast as well as ovarian carcinoma. 9661879 1998
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE BRCA1 5382insC mutation in sporadic and familial breast and ovarian carcinoma in Scotland. 9155062 1997
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE It is not yet known how frequently somatic BRCA1 mutations predispose to breast and ovarian carcinoma in the general female population. 8173065 1993
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2. 28882436 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE To compare BRCA1 mutations in papillary serous carcinoma of the peritoneum and papillary serous ovarian carcinoma. 9764635 1998
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 Biomarker disease BEFREE Aberrant Promoter Hypermethylation of RASSF1a and BRCA1 in Circulating Cell-Free Tumor DNA Serves as a Biomarker of Ovarian Carcinoma. 31653147 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 AlteredExpression disease BEFREE Reduced BRCA1 gene expression is common in the sporadic form of ovarian carcinoma. 23339184 2013
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE Alteration of expression of the tumor suppressor gene BRCA-1 has been widely studied in breast and ovarian carcinoma. 30446260 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE Eligible patients are premenopausal BRCA1/2 mutation carriers after completing childbearing without (a history of) ovarian carcinoma. 26286255 2015
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE At the time of salpingo-oophorectomy, five of 58 BRCA1 carriers (8.6%) were diagnosed with an occult carcinoma: two fallopian tube carcinomas, two ovarian carcinomas and one case was defined as a fallopian tube/ovarian carcinoma. 15083174 2004
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE We propagated a novel BRCA1-null human ovarian cancer cell line UWB1.289 from a tumor of papillary serous histology, the most common form of ovarian carcinoma. 17259345 2007
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 Biomarker disease BEFREE BRCA1/2 pathogenic (P) and likely pathogenic (LP) germline variants are frequent among patients with ovarian carcinoma. 30606148 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE The similar frequency distribution of BRCA1/2 mutations in PPC and OvC observed in the present study indicates that these mutations may predispose to PPC as well and that this neoplasm is part of the hereditary breast-ovarian cancer syndrome. 12504628 2003
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE BRCA2 mutations were less common than BRCA1 mutations in families with any history of ovarian carcinoma. 10717622 2000
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 Biomarker disease BEFREE This study shows that BRCA1 IHC is well correlated with molecular events in ovarian carcinoma. 23232854 2013
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 CausalMutation disease CGI
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE A high proportion of young women with invasive OC have mutations in BRCA1, and a smaller fraction have mutations in other known OC genes. 26718727 2016
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 Biomarker disease BEFREE BRCA-1 and BRCA-2 are tumor suppressor genes in familial breast-ovarian carcinoma syndrome. 11550149 2001
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE Ovarian carcinoma in situ with germline BRCA1 mutation and loss of heterozygosity at BRCA1 and TP53. 10880552 2000
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE Multiple mechanisms cause nearly universal dysfunction of BRCA1 and/or BRCA2 in hereditary and sporadic ovarian carcinoma. 12237285 2002
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		0.500 GeneticVariation disease BEFREE Potent immunogenicity in BRCA1-mutated patients with high-grade serous ovarian carcinoma. 29855141 2018