Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression disease BEFREE P-glycoprotein expression in multidrug-resistant human ovarian carcinoma cell lines. 2565764 1989
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 Biomarker disease BEFREE The inhibition of P-glycoprotein (P-gp) was determined in vitro, and the respective sensitization of doxorubicin-resistant ovarian carcinoma overproducing P-gp was detected. 31416138 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression disease BEFREE Caveolin-1 expression in ovarian carcinoma is MDR1 independent. 11863219 2002
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 Biomarker disease BEFREE The ovarian carcinoma cell line SKOV3 transducted with a human multidrug resistance gene (mdr1) served as the drug resistant model (SKOV3/mdr1). 11780384 2001
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression disease BEFREE Hypermethylation of the analyzed ABCB1 promoter region was significantly correlated with low levels of the ABCB1 transcript in tumors from a subset of patients with breast and ovarian carcinoma prior to chemotherapy but not following treatment. 31173253 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 Biomarker disease BEFREE We therefore investigated the sensitivity of human ovarian carcinoma cells and their P-gp expressing MDR variants to complement. 19040611 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression disease BEFREE Lastly, it was discovered that ABCB1 and CASP2 levels associated with FIGO stage and that the CIT level associated with the time to progression of ovarian carcinoma patients (P<0.0001). 23542236 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression disease BEFREE The expression of the MDR1 gene has been shown to correlate with tumor aggressiveness and oncogenic activation both in experimental tumor models and in human clinical specimens In order to verify whether this association also takes place in ovarian carcinoma, we studied tumor samples from 39 patients by means of immunohistochemistry for the overexpression of P-glycoprotein (MDR1), nm23, c-erb-B2 and p53. 9216679 1997
Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
0.020 Biomarker disease BEFREE Inhibition of multi-drug resistance of ovarian carcinoma by small interfering RNA targeting to MRP2 gene. 18584188 2009
Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
0.020 Biomarker disease BEFREE ABCC2 confers resistance to cisplatin of ovarian carcinoma in cell culture systems and in clinics when expressed in the nuclear membrane. 17145840 2006
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.010 PosttranslationalModification disease BEFREE Furthermore, drug selection with sulfasalazine and topotecan induced a complete demethylation of the ABCG2 promoter in the T-ALL and ovarian carcinoma model cell lines CCRF-CEM and IGROV1, respectively. 20019844 2009
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.010 PosttranslationalModification disease BEFREE The P2 promoter is CpG-rich and susceptible to methylation silencing. p150 expression was restored in OVCA cell lines following growth in the presence of 5-azacytidine. 23273547 2013
Entrez Id: 81
Gene Symbol: ACTN4
ACTN4
0.010 AlteredExpression disease BEFREE ACTN4 RNA and protein expression were associated with advanced and metastatic human ovarian carcinoma. 18362906 2008
Entrez Id: 8038
Gene Symbol: ADAM12
ADAM12
0.010 Biomarker disease BEFREE ADAM12 is a prognostic factor associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma. 25926422 2015
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.010 Biomarker disease BEFREE Plasma adiponectin concentrations were not different in chickens that had ovarian carcinoma compared with control animals. 25700032 2015
Entrez Id: 133
Gene Symbol: ADM
ADM
0.010 Biomarker disease BEFREE Therefore, we presumed that AM could be a potential molecular therapeutic target for ovarian carcinoma. 22400488 2012
Entrez Id: 174
Gene Symbol: AFP
AFP
0.010 Biomarker disease BEFREE Expression of the AFP-V2 mRNA isoform and the wild-type mRNA was differentially regulated, implying that the AFP-V mRNA isoforms could be used in diagnosis and classification of hepatocellular carcinoma and ovarian carcinoma. 19494365 2009
Entrez Id: 100130776
Gene Symbol: AGAP2-AS1
AGAP2-AS1
0.010 AlteredExpression disease BEFREE AGAP2-AS1 overexpression promoted proliferation of OC cells, while MEG3 overexpression inhibited proliferation of OC cells. 31233485 2019
Entrez Id: 79841
Gene Symbol: AGBL2
AGBL2
0.010 Biomarker disease BEFREE In addition, multivariate analysis revealed that AGBL2 could be identified as a potential independent prognostic factor for overall survival in patients with ovarian carcinoma (P=0.004). 31612000 2019
Entrez Id: 26523
Gene Symbol: AGO1
AGO1
0.010 AlteredExpression disease BEFREE In conclusion, Drosha, Dicer, Argonaute 1, and Argonaute 2 are differentially expressed at different metastatic sites in ovarian carcinoma compared with primary carcinomas, suggesting a role for these molecules in tumor progression. 22647351 2012
Entrez Id: 27161
Gene Symbol: AGO2
AGO2
0.010 AlteredExpression disease BEFREE In conclusion, Drosha, Dicer, Argonaute 1, and Argonaute 2 are differentially expressed at different metastatic sites in ovarian carcinoma compared with primary carcinomas, suggesting a role for these molecules in tumor progression. 22647351 2012
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.010 AlteredExpression disease BEFREE The present study examined AT1R expression in human ovarian carcinoma and attempted to determine whether AT1R blocker could suppress the tumor progression. 15814650 2005
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.330 Biomarker disease BEFREE Inhibiting the PI3K/AKT pathway may be a useful treatment for ovarian carcinoma. 25216292 2014
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.330 Biomarker disease BEFREE Although many tumors presented a single lesion (28/93, of which 23 overexpressed PIK3CA, 1 overexpressed AKT and 4 had lost PTEN), many OC (35/93) presented multiple alterations within the PI3K pathway. 23408974 2013
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.330 Biomarker disease BEFREE Our results underline the prognostic significance of PIK3CA in ovarian carcinoma and argue against a simple linear model of PIK3CA gain/amplification followed by PI3K activation and consecutive AKT phosphorylation in ovarian carcinoma. 17377809 2007