Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE The combination of both bradykinin and substance P reporter substances with specific enzyme inhibitors will shed more light on biochemical pathways in inflammatory processes and pain. 31718985 2020
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE Bradykinin (BK) and its receptors, B<sub>1</sub> and B<sub>2</sub>, in trigeminal ganglion (TG) neurons are involved in the regulation of pain. 30182285 2019
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE On the basis of their anatomic location, transient receptor potential ion channels (TRPV1, TRPV2 and TRPM8), Piezo 2, acid-sensing ion channels (ASICs), purinergic (P2X and P2Y), bradykinin (B1 and B2), α-amino-3-hydroxy-5- methylisoxazole-4-propionate (AMPA), N-methyl-D-aspartate (NMDA), metabotropic glutamate (mGlu), neurokinin 1 (NK1) and calcitonin gene-related peptide (CGRP) receptors are activated during pain sensitization. 30706780 2019
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE Bradykinin (BK) is involved in several pathophysiological processes, such as inflammation, pain, cell proliferation, and tumors. 31298304 2019
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE Bradykinin receptor activation is involved in inflammatory reactions, but has never been investigated in fracture pain. 31640792 2019
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE The present study demonstrated (1) the presence and the function of the BK system in endometriosis, (2) activation of BKR induced endothelin-1 in endometriotic lesion and (3) blocking endothelin-1 was effective to decrease pain. 29034546 2018
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype CTD_human Antinociceptive activity of Riparin II from Aniba riparia: Further elucidation of the possible mechanisms. 29655911 2018
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE Significant proteins were identified by MALDI-TOF and tandem MS. <b>Results:</b> In CWP, pain intensity was associated with plasma proteins mostly involved in metabolic and immunity processes (e.g., kininogen-1, fibrinogen gamma chain, and ceruloplasmin), and psychological distress was associated with plasma proteins related to immunity response, iron ion, and lipid metabolism (e.g., complement factor B, complement C1r subcomponent, hemopexin, and clusterin). 30555396 2018
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE Plasma kallikrein, a member of the kallikrein-kinin system, catalyzes the release of the bioactive peptide bradykinin, which induces inflammation, vasodilation, vessel permeability, and pain. 29517911 2018
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception. 29378387 2018
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE Our previous study showed that the μ-opioid receptor agonist fentanyl citrate inhibits endothelin-1-and bradykinin-mediated pain responses in mice orthotopically inoculated with melanoma cells. 27919002 2017
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE IS comprises an acidic combination of bradykinin, serotonin, histamine and prostaglandin PGE2 and was introduced to basic pain research as a tool to activate and sensitize peripheral nociceptors when studying pathological pain conditions associated with allodynia and hyperalgesia. 28167076 2017
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 AlteredExpression phenotype BEFREE These results indicate that simvastatin consistently inhibits mechanical hyperalgesia during neuropathic and inflammatory disorders, possibly by modulating the ascending pain signaling (TRPM8/ASIC/BK pathways expressed in the primary sensory neuron). 28928655 2017
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE The bradykinin-induced rat pain model was used to assess the analgesic effect of tannic acid. 26134502 2015
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE Bradykinin (BK) plays a major role in producing peripheral sensitization in response to peripheral inflammation and in pain transmission in the central nerve system (CNS). 21448919 2012
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE Heightened nociceptor function caused by inflammatory mediators such as bradykinin (BK) contributes to increased pain sensitivity (hyperalgesia) to noxious mechanical and thermal stimuli. 22921401 2012
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype CTD_human Behavioral studies showed greatly reduced thermal inflammatory pain perception in AQP1(-/-) mice evoked by bradykinin, prostaglandin E(2), and capsaicin as well as reduced cold pain perception. 20018876 2010
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 AlteredExpression phenotype BEFREE Unregulated kallikrein activation generates bradykinin, the likely mediator of the swelling and pain characterizing HAE attacks. 17559913 2007
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype CTD_human However, hepatic GSH, which is involved in the detoxification of chemical compounds, significantly decreased after i.p. morphine injection at 02:00 but not at 14:00 h. Overall, the results suggest that the analgesic effect of morphine is greater after dosing during the resting than during the activity phase of mice that have been induced with bradykinin-mediated pain. 16076651 2005
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE Bradykinin is a mediator of inflammation, responsible for pain, vasodilation, and capillary permeability. 15805101 2005
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE The endogenous kallikrein-kinin system controls blood circulation and kidney function, and promotes inflammation and pain in pathological conditions, which has led to interest in developing modulators of bradykinin receptors as potential therapeutics. 15459675 2004
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype BEFREE Roles for the kallikrein-kinin system in inflammatory exudation and pain: lessons from studies on kininogen-deficient rats. 14501145 2003
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype CTD_human Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. 10543429 1999
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype CTD_human Effects of mexiletine on algogenic mediator-induced nociceptive responses in mice. 10445233 1999
Entrez Id: 3827
Gene Symbol: KNG1
KNG1
0.400 Biomarker phenotype CTD_human We also verified that L-NAME (50 mg/kg i.c.) reduced the BK-, but not the CAP- and/or RCM-induced pain responses which suggests that an L-arginine-derived NO or related compound is involved in BK activation of perivascular nociceptors.Indeed, we found that i.c. injection of 20 mg of S-nitrosocysteine, a putative EDRF, caused BK-like responses. 1281941 1992