Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE Over 650 genes were ≥2-fold enriched in adult pDyn nuclei compared with non-pDyn spinal cord nuclei, including targets with known relevance to pain such as galanin (Gal), prepronociceptin (Pnoc), and nitric oxide synthase 1 (Nos1). 31166300 2019
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE Little is known about the mechanisms involved in the regulation of nociceptin and its receptor (nociceptin opioid peptide receptor, NOP) in response to inflammation and pain in humans. 30665329 2019
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE The nonpeptide NOPr antagonist SB-612111 mirrored the favorable effects of UFP-101 in painful and fatigue alterations induced by reserpine. 30720581 2019
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE Insulin-degrading enzyme (IDE) was applied to catalyze hydrolysis of Nociceptin/Orphanin 1-16 (OFQ/N) to show the involvement of the enzyme in degradation of neuropeptides engaged in pain transmission. 31509943 2019
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE The nociceptin/orphanin FQ (N/OFQ) receptor (NOP) is a member of the opioid receptor family and is involved in a number of physiological responses, pain and immune regulation as examples. 30276802 2018
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE Nociceptin/orphanin FQ (N/OFQ) and its NOP receptor constitute the fourth endogenous opioid system that is involved in the control of broad spectrum of biological functions, including pain transmission. 29378191 2018
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE Nocistatin (NST) is a neuropeptide produced from the same precursor protein of opioid peptide nociceptin/orphanin FQ, and it is involved in a broad range of central functions including pain transmission in the nervous system. 29738766 2018
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE Taking advantage from intrathecal application of nociceptin to simultaneously activate NOP on sympathetic preganglionic neurons in the intermediolateral column (IML) and superficial laminae of dorsal horn, we investigated whether the nociceptin-induced cardiovascular effects engage the participation of baroreflex, and whether the concurrently elicited changes in blood pressure and pain responses are interrelated. 30464587 2018
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 AlteredExpression phenotype BEFREE ENK levels were positively correlated (<i>p</i> < 0.01) with the change rates of pain thresholds in the measured nuclei or areas while CCK-8 levels (or OFQ levels) were negatively correlated (<i>p</i> < 0.01) with the pain thresholds in CAU (or CAU and ACB). 30618545 2018
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 GeneticVariation phenotype BEFREE Thus, CC and CC-BS may downregulate OPRL1, consequently inhibiting production of the nociception receptor NOP, leading to pain relief. 30466988 2018
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE Sex Differences in Nociceptin/Orphanin FQ Peptide Receptor-Mediated Pain and Anxiety Symptoms in a Preclinical Model of Post-traumatic Stress Disorder. 30670988 2018
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE Nociceptin (NC), also known as Orphanin FQ, is a brain peptide involved in the regulation of pain, but its role in the endocrine pancreas is poorly understood. 30112574 2018
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE The mechanism by which the NOP receptor agonists regulate pain transmission in these regions is not clearly understood. 29582417 2018
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 AlteredExpression phenotype BEFREE Nociceptin peptide and NOP mRNA increased in the anterior cingulate cortex (ACC) and not in the somatosensory cortex, suggesting a peculiar involvement of this system in pain regulating circuitry. 28000999 2017
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE Nociceptin/orphanin FQ (N/OFQ) modulates several biological functions, including pain transmission via selective activation of a specific receptor named NOP. 28697954 2017
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE In conclusion, we uncovered the sensitization of TRPA1 by Nocistatin, which may represent a novel mechanism how Nocistatin can modulate pain. 27362459 2017
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE During studies on the analysis of the precursor of N/OFQ, we identified a novel neuropeptide produced from the same precursor and named it "nocistatin (NST)".Intrathecal (i.t.) administration of N/OFQ induces pain responses including touch-evoked allodynia and thermal hyperalgesia, and simultaneous administration of NST blocks the allodynia and hyperalgesia induced by N/OFQ. 25345611 2015
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE The nociceptin/orphanin FQ opioid peptide (NOP) receptor is a widely expressed GPCR involved in the modulation of pain, anxiety, and motor behaviors. 26367173 2015
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE These α-helix-constrained mimetics of nociceptin(1-17) had enhanced serum stability relative to unconstrained peptide analogues and nociceptin itself, were not cytotoxic, and displayed potent thermal analgesic and antianalgesic properties in rats (ED₅₀ 70 pmol, IC₅₀ 10 nmol, s.c.), suggesting promising uses in vivo for the treatment of pain and other ORL-1-mediated responses. 25677767 2015
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission. 22311985 2012
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 AlteredExpression phenotype BEFREE NOP and pN/OFQ mRNA expression, quantified by real-time polymerase chain reaction (RT-PCR), was compared between study groups, and associated to opioid medication, pain intensities, and the inflammatory markers procalcitonin (PCT) and interleukin-6. 21324928 2011
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Therapeutic phenotype CTD_human Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys. 19231294 2009
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE Utilizing functional genomics to identify new pain treatments : the example of nociceptin. 12749729 2003
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE The recent development of specific antagonists at the NOP receptor and of NOP receptor or N/OFQ precursor knock-out mice have generated new insights into the role of N/OFQ in pain processing and help to evaluate the N/OFQ-NOP system as a potential target for new analgesic drugs. 12721334 2003
Entrez Id: 5368
Gene Symbol: PNOC
PNOC
0.400 Biomarker phenotype BEFREE Through activation of its receptor, NociR, nociceptin has been linked with several physiological functions in the central nervous system including memory, locomotion, and processing of pain signals. 12950177 2003