| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.350 | Biomarker | phenotype | BEFREE | The findings contribute valuable information that intranasal AVP can treat orthopedic pain after surgery, and AVP could be an option for pain relief by intranasal administration. | 30082217 | 2019 | ||||
|
0.350 | Biomarker | phenotype | BEFREE | LSMEMs demonstrate that treatment with AVP-825 is associated with lower average migraine pain intensity and disability from 10 to 90 minutes and greater within-person consistency across multiple migraine attacks (reduced WPV) from 45 to 120 minutes post-dose compared to oral sumatriptan. | 31062349 | 2019 | ||||
|
0.350 | Biomarker | phenotype | BEFREE | These results from the COMPASS study further demonstrate that treatment with AVP-825 provides earlier onset and more consistent across-episode improvement of pain and migraine-associated symptoms compared with oral sumatriptan, highlighting the clinical advantages of this newly approved intranasal delivery system for low-dose sumatriptan powder. | 28497569 | 2017 | ||||
|
0.350 | Biomarker | phenotype | BEFREE | Copeptin and cortisol were measured five times during an established model of transdermal electrical stimulation designed to assess pain and hyperalgesia. | 28106611 | 2017 | ||||
|
0.350 | Biomarker | phenotype | BEFREE | While most studies comparing treatments measure differences in proportions of patients achieving a dichotomous endpoint at fixed time intervals, in this study we compare trajectories of migraine pain and disability over time for AVP-825 versus 100 mg oral sumatriptan tablets. | 28880380 | 2017 | ||||
|
0.350 | Therapeutic | phenotype | CTD_human | Phenylephrine-induced antinociception: investigations of potential neural and endocrine bases. | 2271928 | 1990 | ||||
|
0.350 | Therapeutic | phenotype | CTD_human | Pain threshold changes in rats following central injection of beta-endorphin, met-enkephalin, vasopressin or oxytocin antisera. | 6094376 | 1984 |