Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.600 Biomarker phenotype BEFREE Subjective pain (assessed by visual analogue scale in pain diary and by chairside archwire activation), periodontal status (assessed by periodontal clinical parameters), cytokines in gingival crevicular fluid (interleukin 1β, prostaglandin E<sub>2</sub>, substance P) and periodontopathic bacteria (Porphyromonas gingivalis and Treponema denticola) in supragingival plaque were assessed. 31833004 2020
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker phenotype BEFREE Intra-mPFC microinjection of naloxonazine (a mu-opioid receptor antagonist, 1 μg/0.25 μL) and AM251 (a cannabinoid CB1 receptor antagonist, 1 μg/0.25 μL) increased both phases of pain intensity. 31641818 2020
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.600 Biomarker phenotype BEFREE The combination of both bradykinin and substance P reporter substances with specific enzyme inhibitors will shed more light on biochemical pathways in inflammatory processes and pain. 31718985 2020
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.600 Biomarker phenotype BEFREE In the central nervous system, substance P participates in the regulation of pain, learning, memory, and sexual homeostasis. 31807924 2020
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.600 GeneticVariation phenotype BEFREE The primary aim of this study was to investigate the effects of the catechol-O-methyltransferase Val158Met polymorphism on heat pain perception in a cohort of adults receiving daily opioid therapy for chronic pain. 31041874 2020
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.600 Biomarker phenotype BEFREE Catechol-O-methyltransferase (COMT) enzyme has a major role in the adjustment of catechol-dependent functions, for example, cognition, cardiac function, and pain processing. 31586564 2020
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.600 GeneticVariation phenotype BEFREE To analyze the association between the rs4680 catechol-O-methyltransferase Val158Met polymorphism and to determine the association of this polymorphism with clinical, psychological, and pain sensitivity variables in women with episodic or chronic migraine. 30481348 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker phenotype BEFREE The endocannabinoid system involving the central nervous system (CNS), the human cannabinoid receptor 1 (CB1), is an important drug target and its variability has implications for disease susceptibility and altered drug and pain response. 31174013 2019
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.600 Biomarker phenotype BEFREE COMT and OPRM1 may be associated with higher pain perception after surgical procedures. 31080143 2019
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.600 GeneticVariation phenotype BEFREE The AA genotype of rs4680 or A_T_C_A/ A_T_C_A (rs6269_rs4633_ rs4818_rs4680) diplotype of COMT, combined with the AG genotype of OPRM1 A118G, showed significantly increased pressure pain threshold from butorphanol. 31806881 2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.600 Biomarker phenotype BEFREE In chronic pain, the substance P (SP) neurokinin 1 receptor (NK<sub>1</sub>R) redistributes from the plasma membrane to acidified endosomes, where it signals to maintain pain. 31686009 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker phenotype BEFREE Considering that the endocannabinoid system via CB1 receptors play a crucial role in pain modulation, we also assessed the possible role of the VH cannabinoid CB1 receptors in the functional interaction between minocycline and morphine in acute pain. 31006075 2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.600 Biomarker phenotype BEFREE Various inhibitors of TRPV1, TRPV2, TRPM8, Piezo 2, ASICs, P2X, P2Y, B1, B2, AMPA, NMDA, mGlu, NK1 and CGRP receptors have shown high therapeutic value in experimental models of pain. 30706780 2019
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.600 GeneticVariation phenotype BEFREE The association between COMT Val158Met polymorphism (rs4680) and the inter-individual differences in the response to opioid analgesic therapy was investigated in a cohort of 87 Italian paediatric patients receiving opioids for cancer pain (STOP Pain study). 30704436 2019
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.600 GeneticVariation phenotype BEFREE Few associations replicated: morphine dose (mcg/kg) in African American children and ABCB1 rs1045642 (A allele, β = -9.30, 95% CI: -17.25 to -1.35, p = 0.02) and OPRM1 rs1799971 (G allele, β = 23.19, 95% CI: 3.27-43.11, p = 0.02); KCNJ6 rs2211843 and high pain in African American subjects (T allele, OR 2.08, 95% CI: 1.17-3.71, p = 0.01) and in congruent European Caucasian pain phenotypes; and COMT rs740603 for high pain in European Caucasian subjects (A allele, OR: 0.69, 95% CI: 0.48-0.99, p = 0.046). 30760877 2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.600 Biomarker phenotype BEFREE The expression of TRPV1, ASIC-3, TDV8 encode ionic channels in RA and modulate the pain, likewise, the transcription factors in RA, such as TNFα, TGF-β1, IL-6, IL-10, IFN-γ, IL-1b, mTOR, p21, caspase 3, EDNRB, CGRP-CALCB, CGRP-CALCA, TAC1 are also directly involved in pain perception. 31419924 2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.600 Biomarker phenotype BEFREE Compounds that inhibit SP's action are being investigated as potential drugs to relieve pain. 30284083 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker phenotype BEFREE In conclusions, both CB1 and PPARα receptors are involved in mediating pain in osteoarthritis. 30945071 2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.600 Biomarker phenotype BEFREE This double-blind, randomized, crossover study compared the local anesthetic effect of CTY-5339A versus 14% benzocaine alone by using 2 quantitative sensory threshold experimental pain paradigms on the maxillary gingiva: pin prick test pain intensity (PPT PI) and heat pain threshold (HPT). 30660443 2019
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.600 Biomarker phenotype BEFREE The joint effects of low COMT and stress on functional pain and depressive-like behavior were significantly greater in females versus males. 31815911 2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.600 Biomarker phenotype BEFREE Membrane metallo-endopeptidase (MME), also known as neprilysin (NEP), has been of interest for its role in neurodegeneration and pain due to its ability to degrade β-amyloid and substance-P, respectively. 31339187 2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.600 Biomarker phenotype BEFREE Substance P is an eleven-amino acid neuropeptide (undecapeptide) with multiple effects on the gastrointestinal, cardiovascular, and urinary systems as well as complex central nervous system functions such as pain, learning, memory, and sexual homeostasis. 31147779 2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.600 Biomarker phenotype BEFREE Moreover, genes associated with neuropathic pain including Maob, Grin2b/NMDAR2b, TrpV3, IL-6, Cacna1b/Ca<sub>v</sub>2.2, Itgam/Cd11b, Scn9a/Na<sub>v</sub>1.7, and Tac1 were all found to respond to the celecoxib loaded nanoemulsion during pain relief as compared to those animals that received drug-free vehicle. 31652890 2019
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.600 GeneticVariation phenotype BEFREE Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache. 30614828 2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.600 Biomarker phenotype BEFREE A possible mechanism for the effect of LLLT on fibromyalgia pain is via the antinociceptive signaling of substance P in muscle nociceptors, although the neuropeptide has been known as a neurotransmitter to facilitate pain signals in the spinal cord. 30908578 2019