Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.380 Biomarker disease BEFREE Interleukin-8 (IL-8) is an angiogenic factor that promotes growth of pancreatic tumors. 16103072 2005
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.380 Biomarker disease BEFREE Furthermore, activated PSCs might exacerbate malignant behavior of cancer cells via IL-8 because suppression of IL-8 signaling reduced pancreatic tumor growth and fibrosis <i>in vivo</i>. 31695760 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.380 Biomarker disease LHGDN GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells. 15609321 2005
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.380 Biomarker disease CTD_human Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. 18307536 2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.380 AlteredExpression disease LHGDN Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. 18307536 2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.380 AlteredExpression disease BEFREE Overexpression of IL-8 in pancreatic tumors is believed to promote tumor angiogenesis and to activate survival signaling pathways. 27749658 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.380 AlteredExpression disease LHGDN Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells. 12632066 2003
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.380 Biomarker disease LHGDN Signal of proteinase-activated receptor-2 contributes to highly malignant potential of human pancreatic cancer by up-regulation of interleukin-8 release. 16525644 2006
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.380 Biomarker disease BEFREE Together, our findings identify IL-8 as an important mediator in the gemcitabine-induced infiltration of macrophages within the pancreatic tumor microenvironment and suggest the requirement of additional mechanism(s) for macrophage polarization. 30097594 2018