×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
AlteredExpression
disease
LHGDN
Expression of Gadd45a and p53 proteins in human pancreatic cancer: potential effects on clinical outcomes.
17230496
2007
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
CausalMutation
disease
CGI
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
AlteredExpression
disease
BEFREE
Collectively, our results show that decreased MGMT expression is correlated with p53 activation, and significantly reduced primary pancreatic tumor growth.
19789303
2009
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
GeneticVariation
disease
BEFREE
Among other somatic mutations, TP53 is mutated in more than 75% of human pancreatic tumors .
29367463
2018
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
Biomarker
disease
CTD_human
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
GeneticVariation
disease
BEFREE
Owing to the high incidence of p53 mutations in PanIN 3 lesions and pancreatic tumors , we interrogated the comparative ability of adult pancreatic acinar and ductal cells to respond to oncogenic Kras and mutant Tp53(R172H ) using Hnf1b:CreER(T2) and Mist1:CreER(T2) mice.
26592447
2016
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.900
Biomarker
disease
CTD_mouse
Functions of TAp63 and p53 in restraining the development of metastatic cancer.
23873029
2014
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
BEFREE
Experiments on subcutaneous pancreatic xenografts demonstrated the effectiveness of p16 in the inhibition of pancreatic tumor growth in vivo.
11687897
2001
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
LHGDN
Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland.
18714178
2008
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
BEFREE
In LSL-Kras(G12D )/Pdx-1-Cre/Ink4a /Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor -free survival.
23980075
2013
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
LHGDN
Genetic testing in familial melanoma: uptake and implications.
18613292
2008
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
BEFREE
This can have implications for screening and for the diagnosis of pancreatic neoplasms in carriers of germline CDKN2A mutations.
31261289
2019
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
AlteredExpression
disease
BEFREE
To directly investigate genetic alterations and expression of p16/MTS1 and p15/MTS2, this study surveyed pancreatic tumors .
8613012
1996
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
AlteredExpression
disease
LHGDN
Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes.
15336553
2004
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
LHGDN
Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRs.
17106238
2006
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
BEFREE
Delivery of ALSV-A-based RCAS vectors encoding either mouse polyoma virus middle T antigen (PyMT) or c-Myc to elastase-tv-a transgenic, Ink4a /Arf null mice induced the formation of pancreatic tumors .
14681205
2003
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
UNIPROT
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
AlteredExpression
disease
BEFREE
The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity.
15309028
2004
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
BEFREE
The INK4a -ARF locus plays a central role in the development of pancreatic tumors as evidenced by the fact that up to 98% of pancreatic tumor specimens harbored genetic alterations at the INK4a -ARF locus.
23727582
2013
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
LHGDN
INK4/ARF germline alterations in pancreatic cancer patients.
14679123
2004
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
HPO
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GeneticVariation
disease
LHGDN
High prevalence of the G101W germline mutation in the CDKN2A (P16(ink4a)) gene in 62 Italian malignant melanoma families.
11807902
2002
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
CTD_human
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
26098869
2015
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
GenomicAlterations
disease
CGI
×
Entrez Id:
1029
Gene Symbol:
CDKN2A
CDKN2A
0.800
Biomarker
disease
BEFREE
The p16INK4a -/retinoblastoma tumour-suppressive pathway has been shown to be involved in the development of near to all pancreatic neoplasms . p14ARF is another tumour suppressor located in the immediate neighbourhood of p16INK4a .
12610506
2003