Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease BEFREE Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1α Inhibitor Impairs Pancreatic Tumor Growth. 30676731 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease BEFREE Hypoxic conditions in the pancreatic tumor microenvironment lead to the stabilization of hypoxia-inducible factor-1 alpha (HIF-1α), which acts as the master regulator of cancer cell metabolism. 29330793 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease BEFREE Here, we investigated the potential importance of a master regulator of the cellular adaptive response to hypoxia, hypoxia-inducible factor-1 (HIF-1), in the formation of stroma-rich microenvironments of pancreatic tumors. 29535824 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease BEFREE Our study suggests that in hypoxic pancreatic tumors PKM2 interferes both with NF-κB/p65 and HIF-1α activation that ultimately triggers VEGF-A secretion and subsequent blood vessel formation. 26739387 2016
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease BEFREE The aim of study was to discuss the correlation and regulatory mechanism of HIF-1 and miR-191 expression in pancreatic tumor. 25119596 2014
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease BEFREE In support of this finding, elevated levels of HIF-1α and SHH in pancreatic tumors were determined to be markers of decreased patient survival. 23633488 2013
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease BEFREE Our data suggest that the β2-AR-HIF-1α axis regulates stress-induced pancreatic tumor growth and angiogenesis. 23745588 2013
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease BEFREE Effect of small interference RNA targeting HIF-1alpha mediated by rAAV combined L: -ascorbate on pancreatic tumors in athymic mice. 18509748 2009
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease LHGDN Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. 18422749 2008
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease LHGDN Identification of thioredoxin-interacting protein 1 as a hypoxia-inducible factor 1alpha-induced gene in pancreatic cancer. 18376310 2008
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease LHGDN High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF. 18592007 2008
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease LHGDN Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers. 17143338 2006
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 Biomarker disease CTD_human Effect of antisense hypoxia-inducible factor 1alpha on progression, metastasis, and chemosensitivity of pancreatic cancer. 16628086 2006
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease LHGDN Proliferating cell nuclear antigen, survivin, and CD34 expressions in pancreatic cancer and their correlation with hypoxia-inducible factor 1alpha. 16552335 2006
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 PosttranslationalModification disease LHGDN Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells. 16278378 2005
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease LHGDN Prognostic significance of HIF-1 alpha overexpression in human pancreatic cancer. 14981919 2004
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.400 AlteredExpression disease LHGDN Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. 12651620 2003