Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | Increased IL-6 along with decreased IFN-γ and cell-mediated cytotoxicity by the NK cells, within NK-adipose tissue of KC/HFCD mice, may provide safe microenvironment for the expansion of pancreatic tumors. | 29977235 | 2018 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | The results confirm that IL-1 is an important driver of inflammation in epithelial pancreatic tumors; however, tumor cells undergoing EMT will likely escape IL-1R inhibition, as IL-6 is continuously transcribed by TWIST. | 29308316 | 2018 | ||||
|
0.070 | AlteredExpression | disease | LHGDN | Identification of an inducible factor secreted by pancreatic cancer cell lines that stimulates the production of fucosylated haptoglobin in hepatoma cells. | 18951869 | 2008 | ||||
|
0.070 | GeneticVariation | disease | LHGDN | Association of IL-6 gene polymorphisms with cachexia susceptibility and survival time of patients with pancreatic cancer. | 18469355 | 2008 | ||||
|
0.070 | Biomarker | disease | LHGDN | Because insulin-like growth factor-I receptor (IGF-IR) and signal transducer and activator of transcription 3 (STAT3) signaling pathways are implicated in the progression of pancreatic cancer, we hypothesized that blocking Hsp90 with geldanamycin derivates [17-allylamino-geldanamycin (17-AAG), 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG)] would impair IGF-I- and interleukin-6-mediated signaling and thus reduce pancreatic tumor growth and angiogenesis in vivo. | 17975158 | 2007 | ||||
|
0.070 | AlteredExpression | disease | LHGDN | Role of mononuclear cells and inflammatory cytokines in pancreatic cancer-related cachexia. | 16115919 | 2005 | ||||
|
0.070 | Biomarker | disease | LHGDN | GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells. | 15609321 | 2005 |