Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Collectively, these findings reveal a highly dynamic and interdependent metabolic, transcriptional, and epigenetic regulatory network governed by Yap, Myc, Sox2, and p53 that dictates pancreatic tumor metabolism, growth, survival, and differentiation. 31447265 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Supernumerary and abnormal centrosomes are observed in the earliest stages of pancreatic tumor development, and the p53 pathway acts as an initial barrier to the proliferation of cells with extra centrosomes. 29491046 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Among other somatic mutations, TP53 is mutated in more than 75% of human pancreatic tumors. 29367463 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE Stat3, Il6st (encodes gp130), or Trp53 were disrupted, or a mutant form of P53 (P53R172H) or transgenic sgp130 were expressed, in mice that developed pancreatic tumors resulting from expression of activated KRAS (KrasG12D, KC mice). 27003603 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Owing to the high incidence of p53 mutations in PanIN 3 lesions and pancreatic tumors, we interrogated the comparative ability of adult pancreatic acinar and ductal cells to respond to oncogenic Kras and mutant Tp53(R172H) using Hnf1b:CreER(T2) and Mist1:CreER(T2) mice. 26592447 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease CTD_mouse Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. 26390243 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE One out of seven Tsc1 (-/-) ; p53 (-/-) animals developed pancreatic tumors showing a distinctive tumor morphology, reminiscent of human ACC. 26683340 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. 24875860 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease CTD_mouse Functions of TAp63 and p53 in restraining the development of metastatic cancer. 23873029 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Surprisingly, little is known about the role and regulation of hdm2 in pancreatic tumors, a large proportion (50-75%) of which contain mutant p53. 19029954 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease LHGDN Surprisingly, little is known about the role and regulation of hdm2 in pancreatic tumors, a large proportion (50-75%) of which contain mutant p53. 19029954 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE Collectively, our results show that decreased MGMT expression is correlated with p53 activation, and significantly reduced primary pancreatic tumor growth. 19789303 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease LHGDN Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations. 18701504 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Furthermore, the identical nucleotide mutation of TP53 gene was observed from both the endometrial and pancreatic tumors. 18577117 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease LHGDN Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer. 17659731 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease LHGDN Pancreatic tumor cell lines, CRL1420, which contains elevated levels of mutant p53, and CRL1682, with no detectable p53 protein, were stably transfected with the exogenous wild-type p53 gene. 17651038 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. 17911264 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease LHGDN Expression of Gadd45a and p53 proteins in human pancreatic cancer: potential effects on clinical outcomes. 17230496 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease LHGDN Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRs. 17106238 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease LHGDN Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. 15846069 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE This suggests that LKB1-induced apoptosis is p53 independent but might be p73-mediated in the pancreatic tumor cell line, AsPC-1. 14511408 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE This study was undertaken to evaluate the impact of wild-type or mutant p53 status on the synergistic effects of 5-Fluorouracil (5-FU) and radiation (XRT) in pancreatic tumors. 12014658 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Gene therapy approaches involving p53 replacement are promising due to the central role of p53 in the cellular response to DNA damage and the high incidence of p53 mutations in pancreatic tumors. 10505853 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Both K-ras and p53 gene mutations are found commonly in pancreatic tumors. 10217065 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE Reduced expression of p53 and cyclin A in intraductal mucin-hypersecreting neoplasm of the pancreas compared with usual pancreatic ductal adenocarcinoma. 10445560 1999