Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.070 AlteredExpression disease BEFREE Clinical significance and peculiarities of succinate dehydrogenase B and hypoxia inducible factor 1α expression in parasympathetic versus sympathetic paragangliomas. 30549360 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.070 AlteredExpression disease BEFREE Collectively, these findings demonstrate the potential importance of both the SDHC epigenomic event and the activation of the HIF-1α/miR-210/ISCU axis in the pathogenesis of SDHx wild-type/SDHB-negative PGLs. 29126304 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.070 AlteredExpression disease BEFREE Thus, activation of HIF-1α is likely an early event in VHL-defective PGLs directly linked to VHL mutations, but it is a late event favored but not directly triggered by SDHx mutations. 28036268 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.070 AlteredExpression disease BEFREE Immunohistochemistry of skull base PGL demonstrated heavy expression of TH and HIF-2α but reduced expression of HIF-1α. 26492543 2016
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.070 AlteredExpression disease BEFREE Identification of somatic VHL gene mutations in sporadic head and neck paragangliomas in association with activation of the HIF-1α/miR-210 signaling pathway. 23902947 2013
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.070 Biomarker disease BEFREE Moderately or highly stabilized HIF1 alpha was present in 68% (26/38) of the PGLs but in PHEOs (n = 16) no such pattern was observed. 17520677 2007
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.070 AlteredExpression disease BEFREE Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations. 16954163 2006