Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | group | BEFREE | A number of genes, put forth as candidate tumor suppressors based on their genomic locations, roles in familial disease, and/or other relevant biological functions, have been examined for pathogenetic mutations in sporadic parathyroid tumors with negative results; these include the calcium-sensing receptor protein (CaR), vitamin-D receptor (VDR), and RET. | 12412775 | 2002 | ||||
|
0.080 | GeneticVariation | group | BEFREE | No somatic RET gene mutations were found in the 129 sporadic parathyroid tumors or 14 parathyroid hyperplastic lesions secondary to uremia. | 10915003 | 2000 | ||||
|
0.080 | GeneticVariation | group | BEFREE | Mutations in the RET gene have been identified as the causal agent in MEN-2 but this gene contributes rarely to development of sporadic parathyroid tumors. | 11706744 | 2000 | ||||
|
0.080 | GeneticVariation | group | BEFREE | Mutations of the RET proto-oncogene contributing to MEN 2 syndromes are absent in sporadic parathyroid tumors. | 9736899 | 1998 | ||||
|
0.080 | Biomarker | group | BEFREE | This study investigated the possibility that RET plays a role in sporadic parathyroid neoplasia. | 8976870 | 1996 | ||||
|
0.080 | Biomarker | group | BEFREE | In addition the HRPT2 gene on 1q, as well as the proto-oncogenes RET on 10q and PRAD1 on 11q are associated with a subset of parathyroid tumors. | 8981014 | 1996 | ||||
|
0.080 | GeneticVariation | group | BEFREE | Our data suggest that parathyroid disease is an integral part of the MEN 2A syndrome, but that MEN 2 mutations in RET rarely play a part in the pathogenesis of sporadic parathyroid tumors. | 8675600 | 1996 | ||||
|
0.080 | GeneticVariation | group | BEFREE | These results suggest that mutations of the RET proto-oncogene do not represent a frequent mechanism of tumorigenesis for parathyroid tumors. | 8616528 | 1996 |