Gene: PARK7 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Mutations of the DJ-1 (PARK7) gene are linked to familial Parkinson's disease. 15784737 2005
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Mutations in the DJ-1 gene cause autosomal recessive early onset PD in two European families. 14713311 2003
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease LHGDN Molecular basis for the structural instability of human DJ-1 induced by the L166P mutation associated with Parkinson's disease. 18707128 2008
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE DJ-1 (PARK7) is a gene linked to autosomal recessive Parkinson disease (PD). 24899725 2014
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Mutations in the DJ-1 gene have been implicated in the PARK7-linked autosomal recessive form of Parkinson's disease (PD). 15519239 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease LHGDN [Association of the DJ-1 gene polymorphism with sporadic Parkinson's disease in Sichuan province of China]. 18841573 2008
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE We characterized the pathophenotypes of dopaminergic neuronal cells that were deficient in PINK1 or DJ-1, genes with mutations linked to familial PD. 21664494 2011
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease LHGDN Genetics of Parkinson disease. 15717024 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease LHGDN Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7). 15365989 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease LHGDN L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. 12851414 2003
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE DJ-1 (also known as PARK7) has been identified as a causal gene for hereditary recessive Parkinson's disease (PD). 28993701 2017
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Mutations in the DJ-1 gene have recently been shown to cause autosomal recessive Parkinson's disease. 14707326 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE However, the relationship between pathogenic mutations in PARK7 and ER stress-induced UPR in PD pathogenesis remains unclear. 30755590 2019
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease. 14625045 2003
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Loss-of-function mutations in DJ-1 (PARK7) gene account for about 1% of all familial Parkinson's disease (PD). 25210784 2014
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Parkin-mediated alterations in DJ-1 protein stability may be pathogenically relevant as DJ-1 levels are dramatically increased in the detergent-insoluble fraction from sporadic PD/DLB brains, but are reduced in the insoluble fraction from parkin-linked autosomal recessive juvenile-onset PD brains. 15525661 2005
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Thus, the PD-associated P158Δ mutation destabilizes DJ-1 protein and function. 23241025 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Mutations in DJ-1 (PARK7) cause recessively inherited Parkinson's disease. 18711745 2009
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE DJ-1 gene deletion exacerbates the progression of Parkinson's disease presumably by augmenting oxidative stress. 27509531 2017
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease LHGDN Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations. 15254937 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Mutations in DJ-1 (PARK7) are a known cause of early-onset autosomal recessive Parkinson's disease (PD). 29386384 2018
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease LHGDN Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients. 15219840 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Data mining for single-nucleotide polymorphisms (SNP), reportedly associated with breast cancer in genome-wide association study (GWAS) that localize to chromosomes bearing known Parkinson's disease predisposition loci: PARK7, PINK1 (chromosome 1); SNCA (chromosome 4); PARK2 (chromosome 6); and LRRK2 (chromosome 12), was carried out. 23765085 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Loss of function mutations of DJ-1 (PARK7) have been linked to the pathogenesis of Parkinson's disease. 29315581 2018
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE The recently developed DJ-1 knockout (KO) rat models the DJ-1 (or PARK7) loss-of-function mutation responsible for one form of early-onset familial Parkinson's disease (PD). 31734455 2020