Gene: PARK7 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE 2-7) and intron boundaries of the DJ-1 gene were screened in 300 individuals (PD, 150; controls, 150) by direct sequencing. 21535932 2011
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker disease BEFREE 6-OHDA: 6-hydroxydopamine; AMPK: AMP-activated protein kinase; ATG: autophagy related; CAV1: caveolin 1; ER: endoplasmic reticulum; FN1: fibronectin 1; GSH: glutathione; IDE: insulin degrading enzyme; IL: interleukin; LDH: lactate dehydrogenase; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MEF: mouse embryonic fibroblast; MTOR: mechanistic target of rapamycin kinase; NAC: N-acetyl-L-cysteine; PARK7/DJ-1: Parkinsonism associated deglycase; PD: Parkinson disease; RPS6KB1/p70S6K: ribosomal protein S6 kinase B1; RPN1: ribophorin I; ROS: reactive oxygen species; ULK1: unc-51 like autophagy activating kinase 1; WT: wild-type. 30112966 2018
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Parkinson disease (PD)-associated genomic deletions and the destabilizing L166P point mutation lead to loss of the cytoprotective DJ-1 protein. 19293155 2009
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker disease BEFREE Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. 23792957 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker disease CTD_human Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. 23792957 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE DJ-1 gene deletion exacerbates the progression of Parkinson's disease presumably by augmenting oxidative stress. 27509531 2017
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker disease BEFREE DJ-1 protein is involved in multiple physiological processes, including Parkinson's disease. 28224045 2017
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker disease BEFREE DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against neurodegeneration in Parkinson's disease. 31054074 2019
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE PARK7/DJ-1 is a known cause of early-onset autosomal-recessive PD and is implicated in neuroprotection against oxidative stress. 31353306 2019
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker disease LHGDN An association study of four common polymorphisms in the DJ1 gene and Parkinson disease (PD) was conducted. 15304593 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE An association study of four common polymorphisms in the DJ1 gene and Parkinson disease (PD) was conducted. 15304593 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease LHGDN Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations. 15254937 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease LHGDN Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD. 14557580 2003
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker disease LHGDN Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease. 16632486 2006
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Both homozygous (L166P, M26I, deletion) and heterozygous mutations (D149A, A104T) in the DJ-1 gene have been identified in Parkinson's disease (PD) patients. 15944198 2005
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker disease LHGDN Causes of Parkinson's disease: genetics of DJ-1. 15503154 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker disease CTD_human Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese. 25149416 2014
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE Data mining for single-nucleotide polymorphisms (SNP), reportedly associated with breast cancer in genome-wide association study (GWAS) that localize to chromosomes bearing known Parkinson's disease predisposition loci: PARK7, PINK1 (chromosome 1); SNCA (chromosome 4); PARK2 (chromosome 6); and LRRK2 (chromosome 12), was carried out. 23765085 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 AlteredExpression disease BEFREE Diagnosis of Parkinson's disease and the level of oxidized DJ-1 protein. 28705587 2018
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker disease BEFREE DJ-1 ( PARK7) has been reported to be causative gene of Parkinson disease and also an oncogene. 29258409 2018
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker disease BEFREE DJ-1 (PARK7) has been implicated in early onset and familial cases of Parkinson's disease (PD). 17599367 2007
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE DJ-1 (PARK7) is a gene linked to autosomal recessive Parkinson disease (PD). 24899725 2014
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease BEFREE DJ-1 (also known as PARK7) has been identified as a causal gene for hereditary recessive Parkinson's disease (PD). 28993701 2017
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation disease LHGDN DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease. 14872018 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker disease BEFREE DJ-1 - a causative agent of familial Parkinson's disease PARK7 - is responsible for inducing antioxidative reaction. 20202083 2010