×
Entrez Id:
6622
Gene Symbol:
SNCA
SNCA
0.700
Biomarker
disease
MGD
×
Entrez Id:
7019
Gene Symbol:
TFAM
TFAM
0.300
Biomarker
disease
MGD
×
Entrez Id:
56652
Gene Symbol:
TWNK
TWNK
0.240
Biomarker
disease
MGD
×
Entrez Id:
10533
Gene Symbol:
ATG7
ATG7
0.230
Biomarker
disease
MGD
×
Entrez Id:
54700
Gene Symbol:
RRN3
RRN3
0.200
Biomarker
disease
MGD
×
Entrez Id:
1352
Gene Symbol:
COX10
COX10
0.200
Biomarker
disease
MGD
×
Entrez Id:
10188
Gene Symbol:
TNK2
TNK2
0.100
GeneticVariation
disease
CLINVAR
×
Entrez Id:
6622
Gene Symbol:
SNCA
SNCA
0.700
GeneticVariation
disease
BEFREE
"Classic" models are based on neurotoxins that selectively target catecholaminergic neurons (such as 6-hydroxydopamine, 1-methyl-1,2,3,6-tetrahydropiridine, agricultural pesticides, etc.), while more recent models employ genetic manipulations that either introduce mutations similar to those find in familial cases of PD (α-synuclein , DJ-1, PINK1, Parkin, etc.) or selectively disrupt nigrostriatal neurons (MitoPark, Pitx3, Nurr1, etc.).
26343921
2015
×
Entrez Id:
4929
Gene Symbol:
NR4A2
NR4A2
0.300
Biomarker
disease
BEFREE
"Classic" models are based on neurotoxins that selectively target catecholaminergic neurons (such as 6-hydroxydopamine, 1-methyl-1,2,3,6-tetrahydropiridine, agricultural pesticides, etc.), while more recent models employ genetic manipulations that either introduce mutations similar to those find in familial cases of PD (α-synuclein, DJ-1, PINK1, Parkin, etc.) or selectively disrupt nigrostriatal neurons (MitoPark, Pitx3, Nurr1 , etc.).
26343921
2015
×
Entrez Id:
6531
Gene Symbol:
SLC6A3
SLC6A3
0.400
Biomarker
disease
BEFREE
"Depressed" caudate and ventral striatum dopamine transporter availability in de novo Depressed Parkinson's disease .
31377233
2019
×
Entrez Id:
43
Gene Symbol:
ACHE
ACHE
0.100
Biomarker
disease
BEFREE
& Heldr., were screened against acetylcholinesterase (AChE ) and butyrylcholinesterase (BChE) associated with Alzheimer's disease as well as tyrosinase (TYR) linked to Parkinson's disease using ELISA microplate assay at 200 μg/mL.
31365785
2019
×
Entrez Id:
590
Gene Symbol:
BCHE
BCHE
0.100
Biomarker
disease
BEFREE
& Heldr., were screened against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE ) associated with Alzheimer's disease as well as tyrosinase (TYR) linked to Parkinson's disease using ELISA microplate assay at 200 μg/mL.
31365785
2019
×
Entrez Id:
7299
Gene Symbol:
TYR
TYR
0.080
Biomarker
disease
BEFREE
& Heldr., were screened against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) associated with Alzheimer's disease as well as tyrosinase (TYR ) linked to Parkinson's disease using ELISA microplate assay at 200 μg/mL.
31365785
2019
×
Entrez Id:
4129
Gene Symbol:
MAOB
MAOB
0.600
AlteredExpression
disease
BEFREE
<b>:</b> Accumulative evidence indicated that the pathologically accumulated metal ions (iron species and Mn<sup>3+</sup>) and abnormally up-regulated monoamine oxidase B (MAOB ) activity induced oxidation of endogenous dopamine (DA) can lead to mitochondria impairment, lysosome dysfunction, proteasome inhibition, and selective DA neuron vulnerability, which is implicated in the pathogenesis of Parkinson's disease (PD ).
31426448
2019
×
Entrez Id:
6622
Gene Symbol:
SNCA
SNCA
0.700
Biomarker
disease
BEFREE
<b>:</b> Aggregated forms of the synaptic protein α-synuclein (αS ) have been proposed to operate as a molecular trigger for microglial inflammatory processes and neurodegeneration in Parkinson´s disease .
31349736
2019
×
Entrez Id:
26269
Gene Symbol:
FBXO8
FBXO8
0.020
Biomarker
disease
BEFREE
<b>Abbreviations used:</b> ANOVA: Analysis of variance; Ca: Calcium; CDCl3: Chloroform; COX: Cyclooxygenase; DMSO: Dimethyl sulfoxide; EA: Elidic acid; EDTA: Ethylene diamine tetraacetic acid; ELISA: Enzyme Linked Immunosorbent Assay; ESI-MS: Electron spray mass spectroscopy; FAs: Fatty acids; FBS : Fetal bovine serum; GC: Gas chromatography; 1HNMR: Hydrogen nuclear magnetic resonance; LA: Linoleic acid; MPP+: 1-Methyl-4-phenylpyridinium; MPTP: 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine; MTT: 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide; <i>N. sativa</i>: <i>Nigella sativa</i>; OA: Oleic acid; PA: Palmitic acid; PBS: Phosphate buffer saline; PC12: Rat pheochromocytoma cell line; PD: Parkinson's disease ; PDA: Photo diode array detector; PGE2: Prostaglandin E2; TLC: Thin layer chromatography; TMPD: N,N,N',N'-tetramethyl-p-phenylenediamine; USA: United states of America.
29200724
2019
×
Entrez Id:
64319
Gene Symbol:
FBRS
FBRS
0.020
Biomarker
disease
BEFREE
<b>Abbreviations used:</b> ANOVA: Analysis of variance; Ca: Calcium; CDCl3: Chloroform; COX: Cyclooxygenase; DMSO: Dimethyl sulfoxide; EA: Elidic acid; EDTA: Ethylene diamine tetraacetic acid; ELISA: Enzyme Linked Immunosorbent Assay; ESI-MS: Electron spray mass spectroscopy; FAs: Fatty acids; FBS : Fetal bovine serum; GC: Gas chromatography; 1HNMR: Hydrogen nuclear magnetic resonance; LA: Linoleic acid; MPP+: 1-Methyl-4-phenylpyridinium; MPTP: 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine; MTT: 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide; <i>N. sativa</i>: <i>Nigella sativa</i>; OA: Oleic acid; PA: Palmitic acid; PBS: Phosphate buffer saline; PC12: Rat pheochromocytoma cell line; PD: Parkinson's disease ; PDA: Photo diode array detector; PGE2: Prostaglandin E2; TLC: Thin layer chromatography; TMPD: N,N,N',N'-tetramethyl-p-phenylenediamine; USA: United states of America.
29200724
2019
×
Entrez Id:
706
Gene Symbol:
TSPO
TSPO
0.070
Biomarker
disease
BEFREE
<b>Abbreviations used:</b> ANOVA: Analysis of variance; Ca: Calcium; CDCl3: Chloroform; COX: Cyclooxygenase; DMSO: Dimethyl sulfoxide; EA: Elidic acid; EDTA: Ethylene diamine tetraacetic acid; ELISA: Enzyme Linked Immunosorbent Assay; ESI-MS: Electron spray mass spectroscopy; FAs: Fatty acids; FBS: Fetal bovine serum; GC: Gas chromatography; 1HNMR: Hydrogen nuclear magnetic resonance; LA: Linoleic acid; MPP+: 1-Methyl-4-phenylpyridinium; MPTP: 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine; MTT: 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide; <i>N. sativa</i>: <i>Nigella sativa</i>; OA: Oleic acid; PA: Palmitic acid; PBS : Phosphate buffer saline; PC12: Rat pheochromocytoma cell line; PD: Parkinson's disease ; PDA: Photo diode array detector; PGE2: Prostaglandin E2; TLC: Thin layer chromatography; TMPD: N,N,N',N'-tetramethyl-p-phenylenediamine; USA: United states of America.
29200724
2019
×
Entrez Id:
1131
Gene Symbol:
CHRM3
CHRM3
0.030
Biomarker
disease
BEFREE
<b>Abbreviations used:</b> ANOVA: Analysis of variance; Ca: Calcium; CDCl3: Chloroform; COX: Cyclooxygenase; DMSO: Dimethyl sulfoxide; EA: Elidic acid; EDTA: Ethylene diamine tetraacetic acid; ELISA: Enzyme Linked Immunosorbent Assay; ESI-MS: Electron spray mass spectroscopy; FAs: Fatty acids; FBS: Fetal bovine serum; GC: Gas chromatography; 1HNMR: Hydrogen nuclear magnetic resonance; LA: Linoleic acid; MPP+: 1-Methyl-4-phenylpyridinium; MPTP: 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine; MTT: 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide; <i>N. sativa</i>: <i>Nigella sativa</i>; OA: Oleic acid; PA: Palmitic acid; PBS : Phosphate buffer saline; PC12: Rat pheochromocytoma cell line; PD: Parkinson's disease ; PDA: Photo diode array detector; PGE2: Prostaglandin E2; TLC: Thin layer chromatography; TMPD: N,N,N',N'-tetramethyl-p-phenylenediamine; USA: United states of America.
29200724
2019
×
Entrez Id:
3933
Gene Symbol:
LCN1
LCN1
0.010
GeneticVariation
disease
BEFREE
<b>Abbreviations used:</b> ANOVA: Analysis of variance; Ca: Calcium; CDCl3: Chloroform; COX: Cyclooxygenase; DMSO: Dimethyl sulfoxide; EA: Elidic acid; EDTA: Ethylene diamine tetraacetic acid; ELISA: Enzyme Linked Immunosorbent Assay; ESI-MS: Electron spray mass spectroscopy; FAs: Fatty acids; FBS: Fetal bovine serum; GC: Gas chromatography; 1HNMR: Hydrogen nuclear magnetic resonance; LA: Linoleic acid; MPP+: 1-Methyl-4-phenylpyridinium; MPTP: 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine; MTT: 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide; <i>N. sativa</i>: <i>Nigella sativa</i>; OA: Oleic acid; PA: Palmitic acid; PBS: Phosphate buffer saline; PC12: Rat pheochromocytoma cell line; PD: Parkinson's disease ; PDA: Photo diode array detector; PGE2: Prostaglandin E2; TLC : Thin layer chromatography; TMPD: N,N,N',N'-tetramethyl-p-phenylenediamine; USA: United states of America.
29200724
2019
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
0.400
Biomarker
disease
BEFREE
<b>Abbreviations used:</b> COX-2: Cyclooxygenase-2; DA: Dopamine; DMC: Demethoxycurcumin; DMRT: Duncan's multiple range test; GSH: Reduced glutathione; GPx: Glutathione peroxidase; IL-1 β: Interleukin-1 β; IL-6: Interleukin-6 ; iNOS: Inducible nitric oxide synthase; PD: Parkinson's disease ; SN: Substantia nigra; SOD: Superoxide dismutase; TBARS: Thiobarbituric acid reactive substances; TNF-α: Tumor necrosis factor-α.
29576695
2019
×
Entrez Id:
6647
Gene Symbol:
SOD1
SOD1
0.400
GeneticVariation
disease
BEFREE
<b>Abbreviations used:</b> COX-2: Cyclooxygenase-2; DA: Dopamine; DMC: Demethoxycurcumin; DMRT: Duncan's multiple range test; GSH: Reduced glutathione; GPx: Glutathione peroxidase; IL-1 β: Interleukin-1 β; IL-6: Interleukin-6; iNOS: Inducible nitric oxide synthase; PD: Parkinson's disease ; SN: Substantia nigra; SOD : Superoxide dismutase; TBARS: Thiobarbituric acid reactive substances; TNF-α: Tumor necrosis factor-α.
29576695
2019
×
Entrez Id:
8678
Gene Symbol:
BECN1
BECN1
0.050
Biomarker
disease
BEFREE
<b>Abbreviations</b>: 3-MA: 3-methyladenine; AD: Alzheimer disease; ATG: autophagy-related; BECN1 : beclin 1; BM: bone marrow; CD: cluster of differentiation; EAE: experimental autoimmune encephalomyelitis; IL: interleukin; INF: interferon; LAP: LC3-associated phagocytosis; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MSCs: mesenchymal stem cells; MTOR: mechanistic target of rapamycin kinase; PD: Parkinson disease ; PtdIns3K: class III phosphatidylinositol 3-kinase; ROS: reactive oxygen species; SLE: systemic lupus erythematosus; SQSTM1: sequestosome 1; TBI: traumatic brain injury; TGF: transforming growth factor; TNF: tumor necrosis factor.
31185790
2020
×
Entrez Id:
2694
Gene Symbol:
CBLIF
CBLIF
0.020
Biomarker
disease
BEFREE
<b>Abbreviations</b>: 3-MA: 3-methyladenine; AD: Alzheimer disease; ATG: autophagy-related; BECN1: beclin 1; BM: bone marrow; CD: cluster of differentiation; EAE: experimental autoimmune encephalomyelitis; IL: interleukin; INF : interferon; LAP: LC3-associated phagocytosis; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MSCs: mesenchymal stem cells; MTOR: mechanistic target of rapamycin kinase; PD: Parkinson disease ; PtdIns3K: class III phosphatidylinositol 3-kinase; ROS: reactive oxygen species; SLE: systemic lupus erythematosus; SQSTM1: sequestosome 1; TBI: traumatic brain injury; TGF: transforming growth factor; TNF: tumor necrosis factor.
31185790
2020
×
Entrez Id:
7939
Gene Symbol:
LAP
LAP
0.010
Biomarker
disease
BEFREE
<b>Abbreviations</b>: 3-MA: 3-methyladenine; AD: Alzheimer disease; ATG: autophagy-related; BECN1: beclin 1; BM: bone marrow; CD: cluster of differentiation; EAE: experimental autoimmune encephalomyelitis; IL: interleukin; INF: interferon; LAP : LC3-associated phagocytosis; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MSCs: mesenchymal stem cells; MTOR: mechanistic target of rapamycin kinase; PD: Parkinson disease ; PtdIns3K: class III phosphatidylinositol 3-kinase; ROS: reactive oxygen species; SLE: systemic lupus erythematosus; SQSTM1: sequestosome 1; TBI: traumatic brain injury; TGF: transforming growth factor; TNF: tumor necrosis factor.
31185790
2020