Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5150
Gene Symbol: PDE7A
PDE7A 		0.010 AlteredExpression disease BEFREE Here, we have used in vitro and in vivo models of Parkinson's disease to study the regulation of PDE7 protein levels. 31473904 2020
Entrez Id: 8630
Gene Symbol: HSD17B6
HSD17B6 		0.010 Biomarker disease BEFREE Abbreviations: 3-MA: 3-methyladenine; AR7: 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine; CMA: chaperone-mediated autophagy; CQ: chloroquine; CSF: cerebrospinal fluid; DDM: n-dodecyl β-D-maltoside; DIV: days in vitro; ELISA: enzyme-linked immunosorbent assay; FACS: fluorescence-activated cell sorting; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GWAS: genome-wide association studies; HSPA8/HSC70: heat shock protein 8; KFERQ: CMA recognition pentapeptide; KI: knockin; LAMP1: lysosomal-associated membrane protein 1; LAMP2A: lysosomal-associated membrane protein 2A; LDH: lactate dehydrogenase; LRRK2: leucine-rich repeat kinase 2; MEF: mouse embryonic fibroblast; NDUFS4: NADH:ubiquinone oxidoreductase core subunit S4; NE: novel epitope; PD: Parkinson disease; RARA/RARα: retinoic acid receptor, alpha; SNCA: synuclein, alpha; TUBB3/TUJ1: tubulin, beta 3 class III; WT: wild-type. 30983487 2020
Entrez Id: 53938
Gene Symbol: PPIL3
PPIL3 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020
Entrez Id: 51693
Gene Symbol: TRAPPC2L
TRAPPC2L 		0.010 GeneticVariation disease BEFREE We further demonstrate melanoma and PD-inferred gene expression to overlap across tissues (correlation: 0.14, 95% CI 0.06 to 0.22; P = 7.87 × 10<sup>-04</sup>) and highlight seven genes including PIEZO1, TRAPPC2L, and SOX6 as potential mediators of the genetic correlation between melanoma and PD. 31845298 2020
Entrez Id: 2520
Gene Symbol: GAST
GAST 		0.010 GeneticVariation disease BEFREE Study 2 extends the validation of the GAS-G-SF to a clinical sample (<i>N</i> = 156; 62 patients with heart disease, 94 patients with Parkinson's disease). 31625412 2020
Entrez Id: 11328
Gene Symbol: FKBP9
FKBP9 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020
Entrez Id: 10241
Gene Symbol: CALCOCO2
CALCOCO2 		0.010 Biomarker disease BEFREE Abbreviations : ACTB: actin beta; ATP5F1B: ATP synthase F1 subunit beta; CALCOCO2: calcium binding and coiled-coil domain 2; CCCP: carbonyl cyanide m-chlorophenylhydrazone; Co-IP: co-immunoprecipitation; EBSS: Earle's balanced salt solution; GFP: green fluorescent protein; HSPD1: heat shock protein family D (Hsp60) member 1; LAMP1: lysosomal associated membrane protein 1; LRRK2: leucine rich repeat kinase 2; IF: immunofluorescence; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MFN2: mitofusin 2; OMM: outer mitochondrial membrane; OPTN: optineurin; PD: Parkinson disease; PINK1: PTEN induced kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; RHOT1: ras homolog family member T1; ROS: reactive oxygen species; TBK1: TANK binding kinase 1; WB: western blot. 30945962 2020
Entrez Id: 2287
Gene Symbol: FKBP3
FKBP3 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020
Entrez Id: 60681
Gene Symbol: FKBP10
FKBP10 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020
Entrez Id: 1540
Gene Symbol: CYLD
CYLD 		0.010 AlteredExpression disease BEFREE <b>Abbreviations</b>: AD: Alzheimer disease; BM: basement membrane; BWM: body wall muscle; CEP: cephalic sensilla; CLEM: correlative light and electron microscopy; CTNS-1: cystinosin (lysosomal protein) homolog; DA: dopaminergic; DAF-2: abnormal dauer formation; ECM: extracellular matrix; FLIM: fluorescence lifetime imaging microscopy; fps: frames per second; GFP: green fluorescent protein; HPF: high pressure freezing; IGF1: insulin-like growth factor 1; INS: insulin; KD: knockdown; LMP: lysosomal membrane permeabilization; MVB: multivesicular body; NOC: nocodazole; PD: Parkinson disease; RFP: red fluorescent protein; RNAi: RNA interference; sfGFP: superfolder GFP; SNCA: synuclein alpha; TEM: transmission electron microscopy; TNTs: tunneling nanotubes; TCSPC: time correlated single photon counting; YFP: yellow fluorescent protein. 31354022 2020
Entrez Id: 7425
Gene Symbol: VGF
VGF 		0.010 Biomarker disease BEFREE Plasma VGF levels may represent a useful biomarker, especially in the early stages of PD. 31713727 2020
Entrez Id: 2281
Gene Symbol: FKBP1B
FKBP1B 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020
Entrez Id: 79184
Gene Symbol: BRCC3
BRCC3 		0.010 AlteredExpression disease BEFREE Interestingly, upregulating cyclin-dependent kinase 5 (Cdk5) increased the expression of BRCC3 in HEK293 cell, while inhibition of Cdk5 decreased the upregulated BRCC3 level in MPP<sup>+</sup>-induced PD cell model. 31787240 2020
Entrez Id: 1497
Gene Symbol: CTNS
CTNS 		0.010 Biomarker disease BEFREE <b>Abbreviations</b>: AD: Alzheimer disease; BM: basement membrane; BWM: body wall muscle; CEP: cephalic sensilla; CLEM: correlative light and electron microscopy; CTNS-1: cystinosin (lysosomal protein) homolog; DA: dopaminergic; DAF-2: abnormal dauer formation; ECM: extracellular matrix; FLIM: fluorescence lifetime imaging microscopy; fps: frames per second; GFP: green fluorescent protein; HPF: high pressure freezing; IGF1: insulin-like growth factor 1; INS: insulin; KD: knockdown; LMP: lysosomal membrane permeabilization; MVB: multivesicular body; NOC: nocodazole; PD: Parkinson disease; RFP: red fluorescent protein; RNAi: RNA interference; sfGFP: superfolder GFP; SNCA: synuclein alpha; TEM: transmission electron microscopy; TNTs: tunneling nanotubes; TCSPC: time correlated single photon counting; YFP: yellow fluorescent protein. 31354022 2020
Entrez Id: 10928
Gene Symbol: RALBP1
RALBP1 		0.010 AlteredExpression disease BEFREE Downregulating the expression of RIP1, RIP3, or MLKL can significantly attenuate MPTP-induced PD. 31506635 2020
Entrez Id: 29978
Gene Symbol: UBQLN2
UBQLN2 		0.010 Biomarker disease BEFREE In addition, those pathological neurofilament accumulations are known in α-synuclein in Parkinson's disease (PD), Aβ and tau in Alzheimer's disease (AD), polyglutamine in CAG trinucleotide repeat disorders, superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP43), neuronal FUS proteins, optineurin (OPTN), ubiquilin 2 (UBQLN2), and dipeptide repeat protein (DRP) in amyotrophic lateral sclerosis (ALS). 31820696 2020
Entrez Id: 5348
Gene Symbol: FXYD1
FXYD1 		0.010 Biomarker disease BEFREE PLM-Index asymmetry (PLM-I difference of >5/h between both sides) was observed less frequently in PD (34% of patients) compared to RLS (77%, P <  0.05) and SDB (59%, P <  0.05; χ2 test). 31609696 2020
Entrez Id: 221302
Gene Symbol: ZUP1
ZUP1 		0.010 Biomarker disease BEFREE Abbreviations: Bafilomycin/BafA: bafilomycin A<sub>1</sub>; DUB: deubiquitinating enzyme; iPSC: induced pluripotent stem cells; MTOR: mechanistic target of rapamycin kinase; MTORC1: MTOR complex 1; nt: non-targeting; PD: Parkinson disease; p-ATG13: phospho-ATG13; PtdIns3P: phosphatidylinositol 3-phosphate; RPS6: ribosomal protein S6; SNPs: single nucleotide polymorphisms; TH: tyrosine hydroxylase; USP24: ubiquitin specific peptidase 24. 30957634 2020
Entrez Id: 7296
Gene Symbol: TXNRD1
TXNRD1 		0.010 Biomarker disease BEFREE Abbreviations: 3-MA: 3-methyladenine; AR7: 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine; CMA: chaperone-mediated autophagy; CQ: chloroquine; CSF: cerebrospinal fluid; DDM: n-dodecyl β-D-maltoside; DIV: days in vitro; ELISA: enzyme-linked immunosorbent assay; FACS: fluorescence-activated cell sorting; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GWAS: genome-wide association studies; HSPA8/HSC70: heat shock protein 8; KFERQ: CMA recognition pentapeptide; KI: knockin; LAMP1: lysosomal-associated membrane protein 1; LAMP2A: lysosomal-associated membrane protein 2A; LDH: lactate dehydrogenase; LRRK2: leucine-rich repeat kinase 2; MEF: mouse embryonic fibroblast; NDUFS4: NADH:ubiquinone oxidoreductase core subunit S4; NE: novel epitope; PD: Parkinson disease; RARA/RARα: retinoic acid receptor, alpha; SNCA: synuclein, alpha; TUBB3/TUJ1: tubulin, beta 3 class III; WT: wild-type. 30983487 2020
Entrez Id: 57532
Gene Symbol: NUFIP2
NUFIP2 		0.010 Biomarker disease BEFREE Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease. 31768670 2020
Entrez Id: 4504
Gene Symbol: MT3
MT3 		0.010 Biomarker disease BEFREE Collectively, our novel findings indicate that the novel oxindole compound GIF-2165X-G1 serves to delay the progression of Parkinson's disease by suppressing oxidative stress. 31799835 2020
Entrez Id: 51661
Gene Symbol: FKBP7
FKBP7 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020
Entrez Id: 2286
Gene Symbol: FKBP2
FKBP2 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020
Entrez Id: 51645
Gene Symbol: PPIL1
PPIL1 		0.010 Biomarker disease BEFREE The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein  α -synuclein in cells and interacts with  α -synuclein oligomers. 31830361 2020
Entrez Id: 4284
Gene Symbol: MIP
MIP 		0.010 Biomarker disease BEFREE All of the parameters investigated showed inverse correlations with PD severity, and there were significant differences among the levels of severity, as well as between the PD and control groups, in terms of the MIP, MEP, FVC, FEV1, and FEF25-75%. 31576908 2020