Administration of BM suppressed the level of pro-inflammatory cytokines, decreased the levels of α-synuclein, and reduced reactive oxygen species (ROS) generation in PD animal model.
Administration of BM suppressed the level of pro-inflammatory cytokines, decreased the levels of α-synuclein, and reduced reactive oxygen species (ROS) generation in PD animal model.
Several preclinical studies have revealed that NDRG2 is implicated in the pathogenesis of many neurological diseases not limited to tumors (mostly glioma in the nervous system), such as stroke, neurodegeneration (Alzheimer's disease and Parkinson's disease), and psychiatric disorders (depression and attention deficit hyperactivity disorder).
Although it may not indicate that exon 2 polymorphisms of TREM2 play a role in the pathogenesis of PD in the Chinese population, our findings described above highlight the relevance of CSF sTREM2 as a promising biomarker and are extremely possible to the therapeutic target for PD in the future.
In addition to the genotypes of rs671, the patients were assessed with the PD sleep scale-2nd version (PDSS-2) and the Epworth sleepiness scale (ESS) for symptoms of daytime and nocturnal sleep disturbances.
In particular, medical specialists refer to the MDS-UPDRS (Movement Disorder Society - sponsored revision of Unified Parkinson's Disease Rating Scale) that is the most widely used clinical scale for PD rating.
In particular, medical specialists refer to the MDS-UPDRS (Movement Disorder Society - sponsored revision of Unified Parkinson's Disease Rating Scale) that is the most widely used clinical scale for PD rating.
In particular, medical specialists refer to the MDS-UPDRS (Movement Disorder Society - sponsored revision of Unified Parkinson's Disease Rating Scale) that is the most widely used clinical scale for PD rating.
In particular, medical specialists refer to the MDS-UPDRS (Movement Disorder Society - sponsored revision of Unified Parkinson's Disease Rating Scale) that is the most widely used clinical scale for PD rating.
In particular, medical specialists refer to the MDS-UPDRS (Movement Disorder Society - sponsored revision of Unified Parkinson's Disease Rating Scale) that is the most widely used clinical scale for PD rating.
Our study provides high-resolution insights into the structure of the PD-associated protein α -synuclein in complex with the most abundant cellular cyclophilin.